Results 121 to 130 of about 140,507 (299)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

An Automated Video Analysis System for Retrospective Assessment and Real-Time Monitoring of Endoscopic Procedures (with Video)

Bioengineering
Background and Aims: Accurate recognition of endoscopic instruments facilitates quantitative evaluation and quality control of endoscopic procedures. However, no relevant research has been reported.
Yan Zhu, Ling Du, Pei-Yao Fu, Zi-Han Geng, Dan-Feng Zhang, Wei-Feng Chen, Quan-Lin Li, Ping-Hong Zhou   +7 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Automatic cutting and suturing control system based on improved FP16 visual recognition algorithm

International Journal of Advanced Robotic Systems
Objective This study aims to develop and evaluate an autonomous surgical system based on the Toumai laparoscopic surgical robot, focusing on improving the precision and reliability of automated cutting and suturing operations. Methods The proposed system
Jiayin Wang, Weidong Zhao
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Enhancing remanent magnetization of injectable hydrogels improves realtime transluminal localization of tumor in hollow soft viscera

Bioactive Materials
The accuracy of intraoperative localization of tumors undetectable under optical visualization determines surgical quality and survival outcomes in gastrointestinal cancers. Current approaches, however, remain constrained by suboptimal spatial resolution
Junnan Gu, Yuxuan Sun, Tianyi Zhang, Zhenxing Jiang, Falong Zou, Denglong Cheng, Wentai Cai, Hao Wen, Shenghe Deng, Jun Wang, Shuang Zhao, Quanliang Cao, Yinghao Cao, Zichun Yang, Liang Li, Jun Ouyang, Kailin Cai   +16 more
doaj   +1 more source

Treatment Rate Of Second Mesio-Buccal Canals In Maxillary Molars In A Musod Endodontic Resident Patient Population [PDF]

, 2013
Purpose: The primary reason for non-surgical root canal treatment (NSRCT) failure in an upper molar is inadequate cleaning, shaping and filling of the second mesio-buccal root canal (MB2). Failure to locate and treat a present MB2 will lead to a worsened
Margel, Ryan Yale
core   +1 more source

Real-Time Surgical Instrument Defect Detection via Non-Destructive Testing

Defective surgical instruments pose serious risks to sterility, mechanical integrity, and patient safety, increasing the likelihood of surgical complications. However, quality control in surgical instrument manufacturing often relies on manual inspection, which is prone to human error and inconsistency.
Ain, Qurrat Ul, Jilani, Atif Aftab Ahmed, Shafqat, Zunaira, Butt, Nigar Azhar   +3 more
openaire   +2 more sources