Results 91 to 100 of about 917,628 (305)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Clinical and translational research on cancer of the stomach and gastroesophageal junction: A pathologist's view

Clinical and Translational Discovery
Adenocarcinomas of the stomach and gastroesophageal junction remain one of the most common malignant tumours in humans worldwide, often with a poor prognosis.
Christoph Röcken
doaj   +1 more source

Performance of a web-based method for generating synoptic reports

Journal of Pathology Informatics, 2017
Context: The College of American Pathologists (CAP) requires synoptic reporting of all tumor excisions. Objective: To compare the performance of different methods of generating synoptic reports.
Megan A Renshaw, Scott A Renshaw, Mercy Mena-Allauca, Patricia P Carrion, Xiaorong Mei, Arniris Narciandi, Edwin W Gould, Andrew A Renshaw   +7 more
doaj   +1 more source

Appendiceal abscess in a giant left-sided inguinoscrotal hernia: a rare case of Amyand hernia [PDF]

, 2015
The hernia of Amyand is an inguinal hernia containing the appendix in the sac. It is a rare pathology often diagnosed only intra-operatively. We report a case even more rare of a giant left-sided inguinoscrotal Amyand hernia with appendiceal abscess ...
Custureri, Filippo, D'Orazi, Valerio, DE ANNA, Livia, Livadoti, Giada, Maturo, Alessandro, Mongardini, Massimo, Urciuoli, Paolo   +6 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Unveiling a Surgical Revolution: The Use of Conventional Histology versus Ex Vivo Fusion Confocal Microscopy in Breast Cancer Surgery

Cells
Ex vivo fusion confocal microscopy (EVFCM) enables the rapid examination of breast tissue and has the potential to reduce the surgical margins and the necessity for further surgeries.
Daniel Humaran, Javiera Pérez-Anker, Pedro L. Fernández, Lidia Blay, Iciar Pascual, Eva Castellà, Laia Pérez, Susana Puig, Josep Malvehy, Joan F. Julián   +9 more
doaj   +1 more source

Method for coregistration of optical measurements of breast tissue with histopathology : the importance of accounting for tissue deformations [PDF]

, 2019
For the validation of optical diagnostic technologies, experimental results need to be benchmarked against the gold standard. Currently, the gold standard for tissue characterization is assessment of hematoxylin and eosin (H&E)-stained sections by a ...
de Boer, Lisanne L., Kho, Esther, Nijkamp, Jasper, Ruers, Theo J. M., Sterenborg, Henricus J. C. M., ter Beek, Leon C., Van de Vijver, Koen   +6 more
core   +3 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A literature review on surgery for cervical vagal schwannomas [PDF]

, 2015
Cervical vagal schwannoma is a benign, slow-growing mass, often asymptomatic, with a very low lifetime risk of malignant transformation in general population, but diagnosis is still a challenge.
A Peyvandi, A Ziadi, AL Moroni, BK Lahoti, D Biswas, E Langner, EN Callum, GC Kang, Giada Pattaro, Gianfranco Silecchia, Giuseppe Cavallaro, H Liu, J Valentino, JL Roh, KC Chiun, KR Hwang, L Rogers, Marcello Avallone, MG Chiofalo, MJ Gibber, MK Bhayani, MR Sreevatsa, NG McGuire, Olga Iorio, R Bilancia, R Matsuo, R Yasumatsu, RI Rückert, RM Lee, RS Murley, SH Kim, T Ogawa   +31 more
core   +2 more sources