Results 111 to 120 of about 2,137,747 (299)

The surgical pathology of bilharziasis.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2000
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openaire   +2 more sources

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Possibilities of ultrasound in perioperative medicine. A tribute to fashion or the need for clinical search for a surgeon?

Perioperative Medicine, 2019
This article discusses the possibilities of ultrasound in perioperative medicine, namely in the ultrasound study of the superficial organs, lungs, thyroid gland and other internal organs.
Kateryna Dmytriіeva
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Immunohistochemistry of pulmonary biomarkers a perspective from members of the pulmonary pathology society

, 2017
The use of immunohistochemistry for the determination of pulmonary carcinoma biomarkers is a well-established and powerful technique. Immunohistochemisty is readily available in pathology laboratories, is relatively easy to perform and assess, can ...
Rekhtman, Natasha, Hariri, Lida P., Natasha Rekhtman, Sylvie Lantuejoul, Dara L. Aisner, Raparia, Kirtee, Teodora Radonic, Ming Sound Tsao, Capelozzi, Vera L., Aisner, Dara L., Lynette M. Sholl, Izidor Kern, Roy-Chowdhuri, Sinchita, Erik Thunnissen, Vera Luiza Capelozzi, Allen, Timothy C., Prudence Russell, Adam, Julien, Mino-Kenudson, Mari, Wendy Cooper, Mari Mino-Kenudson, Schneider, Frank, Allen, Timothy Craig, Ross Miller, Philip T. Cagle, Julien Adam, Frank Schneider, Cooper, Wendy A. (R14282), Cooper, Wendy, Thunnissen, Erik, Lantuejoul, Sylvie, Yatabe, Yasushi, Tsao, Ming Sound, Lida P. Hariri, Sholl, Lynette M., Yasushi Yatabe, Capelozzi, Vera Luiza, Radonic, Teodora, Sinchita Roy-Chowdhuri, Miller, Ross, Beasley, Mary Beth, Borczuk, Alain C., Kern, Izidor, Mary Beth Beasley, Marina Vivero, Alain C. Borczuk, Cagle, Philip T., Vivero, Marina, Kirtee Raparia, Russell, Prudence, Timothy Craig Allen   +50 more
core   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Unveiling a Surgical Revolution: The Use of Conventional Histology versus Ex Vivo Fusion Confocal Microscopy in Breast Cancer Surgery

Cells
Ex vivo fusion confocal microscopy (EVFCM) enables the rapid examination of breast tissue and has the potential to reduce the surgical margins and the necessity for further surgeries.
Daniel Humaran, Javiera Pérez-Anker, Pedro L. Fernández, Lidia Blay, Iciar Pascual, Eva Castellà, Laia Pérez, Susana Puig, Josep Malvehy, Joan F. Julián   +9 more
doaj   +1 more source