Results 131 to 140 of about 2,278,162 (304)

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Carcinoma papilar de tiroides en niños y adolescentes: relación de las características patológicas con la recurrencia Thyroid papillary carcinoma in children and adolescents: relationship of pathological characteristics with recurrence

Revista Colombiana de Cirugía, 2007
Introducción. El carcinoma papilar en jóvenes tiene un mejor pronóstico que en adultos, a pesar de que se presenta en etapas más avanzadas, tiene un mayor número de recurrencias regionales y su tratamiento puede llevar a un mayor número de complicaciones.
Álvaro Sanabria, Sergio Zúñiga
doaj  

Gastric stump: a malignancy promoter?

, 1990
THE AMERICAN JOURNAL OF SURGICAL PATHOLOGY (NEW ...
LAURINO L., MELATO, MAURO
core  

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Algorithm for Managing Patients Hospitalized in the Surgical Wards Due to COVID-19-Related Acute Abdominal Pathology

Неотложная медицинская помощь
AIM OF THE STUDY. Was to improve the outcomes of treatment of patients with COVID-19-related acute abdominal pathology by developing and implementing an algorithm for the diagnosis and treatment of those patients.MATERIAL AND METHODS.
D. G. Buribayev, D. B. Tulyaganov, Kh. E. Anvarov   +2 more
doaj   +1 more source

A new type of peritoneal encapsulation of the small bowel.

, 1998
THE AMERICAN JOURNAL OF SURGICAL PATHOLOGY (NEW ...
JONJIC N., MELATO, MAURO, DI NUNNO F., COSTANTINIDES, FULVIO, BERNASCONI P.   +4 more
core  

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source

Computer-aided Monitoring of Surgical Pathology Workflow

, 2009
ObjectiveTo explore the feasibility of computer-aided monitoring of surgical pathology workflow.Materials and MethodsWe analyzed the four subprocesses in the surgical pathologic process: (1) arranging surgical pathology examination to receipt of the ...
Chien, Sou-Hsin, Lin, Chin-Lon, Lin, Kuan-Chung, Chang, Shu-Mei, Tseng, Chih-En, Huang, Shi-Shie   +5 more
core   +1 more source