Results 171 to 180 of about 1,461,330 (339)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Two hearts beat as one: An easy method to design a hard flap

open access: yesTurkderm Turkish Archives of Dermatology and Venereology, 2021
Leyla Huseynova, Gonca Elçin
doaj   +1 more source

Preparation and characterization of renal cell peptides from fetal rats for their antitumor activity

open access: yesFEBS Open Bio, EarlyView.
This study aimed to prepare renal cells (RCs) from fetal rats which were digested by enzymes. Candidate peptides RCPs were characterized by capillary HPLC and MS and their bioactivity was predicted using peptideranker. The predicted top 10 bioactive peptides were synthesized.
Zhe Zhang   +6 more
wiley   +1 more source

Evaluating the Effectiveness and Complications of Robotic vs Other Surgery Techniques for Mitral Valve Repair or Replacement: A Comprehensive Systematic Review and Meta-analysis

open access: yesInternational Journal of Medical Students
BACKGROUND: Mitral valve repair and replacement are common critical surgical procedures. Traditional open-heart surgery has long been the standard approach, offering reliable outcomes through direct visualization and access to the heart.
Carlos Esteban Vidal Valderrama   +10 more
doaj  

Burrow’s graft: A simple and time-saving alternative for nasal skin repair after surgery

open access: yesTurkderm Turkish Archives of Dermatology and Venereology, 2021
Leyla Huseynova Terzi, Gonca Elçin
doaj   +1 more source

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