Results 241 to 250 of about 1,643,518 (313)

Surgical resection of pleural lipoma after 9 years of serial imaging. [PDF]

J Cardiothorac Surg
Nahal C, Purohit C, Toma A, Seirafi P.
europepmc   +1 more source

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

Advanced Science, EarlyView.
ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu, Wanying Xiang, Xinyue Wang, Yue Pan, Jing Gao, Jiezhen Yang, Yufei Wang, Zhipu Zhu, Man Tong, Lei Jin, Yan Ye   +10 more
wiley   +1 more source

Surgical resection of longitudinal vaginal septum improves fertility and reproductive capacity in mice. [PDF]

Reprod Fertil
Solomon AE, Ashkenazi Y, Chaves Rivera MN, Bell S, Burzynski CA, Kliman HJ, Tal A, Tal R.   +7 more
europepmc   +1 more source

Tissue‐Agnostic Cellular Morphometric Biomarkers for Risk‐Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers

Advanced Science, EarlyView.
An interpretable, unsupervised artificial intelligence framework identifies a 13‐cellular morphometric biomarker (CMB) signature from routine H&E whole‐slide images. Validated across 2,602 patients, the fixed signature generalizes across colorectal, gastric, and esophageal tissues without retraining, stratifies prognosis and precancerous lesion risk ...
Pin Wang, Chengfei Jiang, April W. Mao, Qi Sun, Yijun Lu, Jingjing Wei, Jamie L. Inman, Susan E. Celniker, Antoine M. Snijders, David W. Threadgill, Allan Balmain, Bo Hang, Hang Chang, Lei Wang, Jian‐Hua Mao   +14 more
wiley   +1 more source

Surgical resection with postoperative stereotactic radiosurgery versus stereotactic radiosurgery alone for large (>3 cm) multiple brain metastases: a propensity score-matched analysis. [PDF]

Front Oncol
Guo X, Wang K, Shi S, Wang L, Zhao Y, Xiao D, Jia W, Sun S, Li D.   +8 more
europepmc   +1 more source

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source

Early recurrence of mitral annular calcification-related calcified amorphous tumor despite complete surgical resection. [PDF]

J Cardiol Cases
Hagiwara Y, Miyake M, Sumiyoshi S, Noguchi Y, Nakagawa S, Sakamoto J, Kondo H, Uehara K, Tamura T.   +8 more
europepmc   +1 more source

Complete symptomatic resolution following surgical resection of a spinal tanycytic ependymoma: a case report. [PDF]

J Med Case Rep
Karaja S, Al-Shami K, Borghol W, Alkassem M, Jarbouh H, Tamer WA.   +5 more
europepmc   +1 more source