Results 61 to 70 of about 1,643,518 (313)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Adenomatous neoplasia in the papilla of Vater endoscopic and/or surgical resection?

, 2022
Background: Adenomatous neoplasia in the papilla of Vater needs to be resected in order not to progress. It can be challenging to distinguish between early ampullary malignant lesions and non-invasive adenomas, due to the overlap in symptoms and ...
Valente, Roberto,, Haraldsson, E, Halimi, A, Arnelo, Urban,, Rangelova, E, Haraldsson, Erik,, Valente, R, Arnelo, U,, Löhr, J. Matthias,, Rangelova, Elena,, Lohr, JM, Halimi, Asif,   +11 more
core   +1 more source

Surgical resection and overall survival in cT4b sinonasal non‐squamous cell carcinoma

Laryngoscope Investigative Otolaryngology
Objective Surgical resection is associated with higher overall survival (OS) than definitive radiotherapy (RT) or chemoradiotherapy (CRT) in cT4b sinonasal squamous cell carcinoma (SCC).
Aman M. Patel, Afash Haleem, Lucy Revercomb, Jason A. Brant, Michael A. Kohanski, Nithin D. Adappa, James N. Palmer, Jennifer E. Douglas, Ryan M. Carey   +8 more
doaj   +1 more source

High-Risk Neuroblastoma: A Surgical Perspective

Children, 2023
High-risk neuroblastoma requires multimodal treatment including systemic chemotherapy, surgical resection, radiation therapy, stem cell transplant, and immunotherapy.
Jillian C. Jacobson, Rachael A. Clark, Dai H. Chung   +2 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Post-surgical Pancreatitis Masquerading as Recurrent Neuroendocrine Cancer [PDF]

, 2010
Neuroendocrine tumours of the pancreas can have a spectrum of behaviour from relatively benign to aggressive. Resection can result in cure although metastatic disease is described.
Oniscu, Anca, Stephen J Wigmore, Adair, Anya, Wigmore, Stephen J, Anya Adair, Anca Oniscu   +5 more
core   +1 more source

Treatment of Synchronous Liver Metastases from Gastric Cancer: A Single-Center Study

Cancer Management and Research, 2020
Pengfei Yu, Yanqiang Zhang, Zeyao Ye, Xiangliu Chen, Ling Huang, Yian Du, Xiangdong Cheng Department of Gastric Surgery, Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese ...
Yu P, Zhang Y, Ye Z, Chen X, Huang L, Du Y, Cheng X   +6 more
doaj  

Oncological outcomes after hepatic resection and/or surgical microwave ablation for liver metastasis from gastric cancer

Asian Journal of Surgery, 2019
Summary: Background: Indications and efficacy of surgical treatment for liver metastases from gastric cancer (LMGCs) remain controversial. This retrospective study was designed to clarify the benefits of surgical treatment and identify prognostic ...
Tomoki Ryu, Yuko Takami, Yoshiyuki Wada, Masaki Tateishi, Hajime Matsushima, Munehiro Yoshitomi, Hideki Saitsu   +6 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Comparison of the prognostic value of tumour and patient related factors in patients undergoing potentially curative surgery for colon cancer [PDF]

, 2010
<b>Aim</b>: To comprehensively compare the prognostic value of tumour and patient-related factors in patients undergoing curative surgery for colon cancer.
Roxburgh, C.S.D., Guthrie, G., Wallace, A.M., McMillan, D.C., Horgan, P.G.   +4 more
core   +1 more source