Results 71 to 80 of about 438,352 (293)

Clinical Characteristics and Outcomes Among Individuals With Spinal Implant Infections: A Descriptive Study. [PDF]

, 2016
Little is known about the clinical presentation and outcomes associated with spinal implant infections. Here, we describe a single center's experience in a retrospective cohort of 109 individuals with spinal implant infections, including clinical ...
Baxi, Sanjiv M, Doernberg, Sarah B, Grill, Marie F, Liu, Catherine, Robinson, Makeda L, Schwartz, Brian S   +5 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Impact of a Pharmacist-Driven Penicillin Allergy De-Labeling Pilot Program in Preoperative Cardiothoracic and Spine Surgery Patients at a Quaternary Hospital

Allergies
Documented penicillin allergies are associated with an increased risk of surgical site infections (SSIs), and first-line antibiotics (e.g., cefazolin) are associated with a lower risk of SSIs.
Hannah Crum, Brandon Gagnon, Alexis Thumann, Abbey Sidebottom, Marc Vacquier, Krista Gens   +5 more
doaj   +1 more source

Surgical Site Infections and Antimicrobial Resistance Pattern

Journal of Nepal Health Research Council, 2017
Background: Post-operative surgical site infections (SSIs) are among the leading cause of morbidity and increased medical expense. The aim of this study is to isolate identify and study antimicrobial susceptibility pattern of microorganism from surgical
Raskin Chaudhary, Shrawan Kumar Thapa, Jid Chani Rana, Pradeep Kumar Shah   +3 more
doaj   +1 more source

A preliminary study of the effect of closed incision management with negative pressure wound therapy over high-risk incisions [PDF]

, 2015
Background Certain postoperative wounds are recognised to be associated with more complications than others and may be termed high-risk. Wound healing can be particularly challenging following high-energy trauma where wound necrosis and infection ...
A Colli, A Koski, A Li, A Wackenfors, A Wackenfors, AE Guille, BJ Stanley, CJ Jordan, D Herscovici Jr, DA Mendonca, David M. R. Sajik, DR Holt, DV Kipaldi, E Krug, EJ Harvey, EJ Timmenga, GI Taylor, GK Berry, GW Stanway, J Bertran, J Compston, J Kanis, JC Murrell, JP Stannard, JP Stannard, JS Weese, JT Thompson, JW Fox, Karen L. Perry, KV Lambert, L Holton, LJ Owen, Lynda Rutherford, M Demaria, M Pachowsky, MF Fay, Mieghan Bruce, MJ Allen, MJ Morykwas, MJ Morywkas, MJ Morywkas, MW Bohling, MW Bohling, N Fitzpatrick, NA Abidi, PC Bristow, PE Banwell, PE Banwell, PM Taylor, R Ben Amotz, R Burkhardt, R Petzina, RP Wilkes, S Karlakki, S Lindstedt, SA Robertson, SP Roch, SZ Chen, TJ Smith, WT DeCarbo   +59 more
core   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The inter-rater reliability of the diagnosis of surgical site infection in the context of a clinical trial. [PDF]

, 2016
ObjectivesThe diagnosis of surgical site infection following endoprosthetic reconstruction for bone tumours is frequently a subjective diagnosis. Large clinical trials use blinded Central Adjudication Committees (CACs) to minimise the variability and ...
Bhandari, M, Deheshi, B, Evaniew, N, Ferguson, P, Ghert, M, Griffin, A, McKay, P, Nuttall, J, O'Shea, T, Randall, RL, Schneider, P, Thornley, P, Turcotte, R, Wunder, J   +13 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Incidence and risk factors of surgical site infection following cesarean section: a retrospective cohort study

Critical Public Health
Background Surgical site infections (SSIs) are a significant concern in developing countries, with prevalence rates affecting a substantial portion of patients undergoing surgical procedures.
Alexis Kamanutse Habimana, Mochama Monica, Mojeed A. Gbadamosi   +2 more
doaj   +1 more source