Results 131 to 140 of about 100,663 (270)

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Time‐ and cost‐effective manufacturing of 3D templates of the pelvis and acetabulum in primary and revision hip arthroplasty using semiautomatic segmentation

Journal of Experimental Orthopaedics
Purpose To develop and evaluate a time‐ and cost‐efficient workflow for generating three‐dimensional (3D) printable models of the pelvis and acetabulum using semiautomated segmentation with free and open‐source software.
Hendrik Pott, Peter Savov, Ricarda Stauss, Julian‐Arman Beheshty, Felix Thormann, Max Ettinger, Stephan Brand   +6 more
doaj   +1 more source

Positive‐Tone Nanolithography of Antimony Trisulfide with Femtosecond Laser Wet‐Etching

Advanced Functional Materials, EarlyView.
A butyldithiocarbamic acid (BDCA) etchant is used to fabricate various micro‐ and nanoscale structures on amorphous antimony trisulfide (a‐Sb2S3) thin film via femtosecond laser etching. Numerical analysis and experimental results elucidate the patterning mechanism on gold (reflective) and quartz (transmissive) substrates.
Abhrodeep Dey, Uwe Hübner, Albane Benardais, Xiaofei Wu, Andrea Dellith, Jan Dellith, Torsten Wieduwilt, Henrik Schneidewind, Markus A Schmidt, Virginie Nazabal, Volker Deckert, Jer‐Shing Huang, Wei Wang   +12 more
wiley   +1 more source

Host‐Directed Biomaterials for Combatting Bloodstream Infections: From Macrocyclic Peptides to Immune‐Activating Cell Backpacks

Advanced Functional Materials, EarlyView.
Bloodstream infections (BSI) are one of the leading causes of mortality and morbidity in both civilian and military populations. This paper summarizes recent progress in novel treatment strategies to manage BSI arising from both bacterial and fungal pathogens using molecules, particles, and materials to elicit host‐directed immunity.
Thomas Thomou, Jagadish Krishnappa, Justin B. Schaal, Prasad Tongaonkar, Dat Q. Tran, Wenchao Gu, Yung‐Fu Chang, Michael E. Selsted, Shaoyi Jiang, Samir Mitragotri, Michael Super, Christopher J. Bettinger   +11 more
wiley   +1 more source

Functional And Aesthetic Maxillary Reconstruction With Digital Zygomatic Obturator Prostheses

International Dental Journal
Aim or purpose: To evaluate the efficacy of a fully digital workflow integrating zygomatic implant-supported obturator prostheses for immediate and secondary rehabilitation of maxillary defects post-tumor resection. Materials and methods: A retrospective
Zhen Wang, Liu Jiannan, Hu Yongjie
doaj   +1 more source

A Bespoke Programmable Interpenetrating Elastomer Network Composite Laryngeal Stent for Expedited Paediatric Laryngotracheal Reconstruction

Advanced Functional Materials, EarlyView.
A programmable interpenetrating double‐network architecture, created via 3D‐TIPS printing and resin infusion, synergistically combines thermoplastic and thermosetting elastomers to balance structural rigidity and surface softness—crucial for paediatric laryngeal stents.
Elizabeth F. Maughan, Lei Wu, Dong Zhang, Linxiao Wu, Graca Ferreira Vaz Pinto Mendes, Wanqiao J. Tu, Heping Ma, Toby J. Proctor, Colin R. Butler, Thomas Kjærgaard, Mark W. Lowdell, Martin A. Birchall, Robert E. Hynds, Richard Hewitt, Wenhui Song   +14 more
wiley   +1 more source

MOFs and COFs in Electronics: Bridging the Gap between Intrinsic Properties and Measured Performance

Advanced Functional Materials, EarlyView.
Metal‐organic frameworks (MOFs) and covalent organic frameworks (COFs) hold promise for advanced electronics. However, discrepancies in reported electrical conductivities highlight the importance of measurement methodologies. This review explores intrinsic charge transport mechanisms and extrinsic factors influencing performance, and critically ...
Jonas F. Pöhls, R. Thomas Weitz
wiley   +1 more source

Unleashing the Power of Machine Learning in Nanomedicine Formulation Development

Advanced Functional Materials, EarlyView.
A random forest machine learning model is able to make predictions on nanoparticle attributes of different nanomedicines (i.e. lipid nanoparticles, liposomes, or PLGA nanoparticles) based on microfluidic formulation parameters. Machine learning models are based on a database of nanoparticle formulations, and models are able to generate unique solutions
Thomas L. Moore, Cristiano Pesce, Antonietta Greco, Claudia Pisante, Greta Avancini, Valentina Di Francesco, Yosi Shamay, Paolo Decuzzi   +7 more
wiley   +1 more source

A Technique to Integrate a Simultaneous Tooth- and Bone-Supported Surgical Guide for Lateral Sinus Lift and Precision Corticotomy

Oral
Background/Objectives: Surgical guides have been used in a variety of dental procedures, such as implant placement to improve clinical accuracy and reduce post-operative complications.
Andrew B. Cameron, Ranu Acharya, Lavanya Ajay Sharma, Tyng-Tyng Lee, Peng Shao, Ajay Sharma   +5 more
doaj   +1 more source

Coordinated Multi‐Component Gradient Engineering of Catalyst Layers for Advanced Polymer Electrolyte Fuel Cells

Advanced Functional Materials, EarlyView.
This work presents a continuous linear gradient catalyst layer design, a general strategy for improving membrane electrode assemblies across electrochemical devices. Fabricated via a dual‐nozzle spray coating method, the architecture controls the Pt/carbon ratio, ionomer content and ionomer type across the catalyst layer, enhancing proton conduction ...
Shangwei Zhou, Matt P. Tudball, Yiming Guo, Bia Brandt, Adam Zucconi, Wenjia Du, Junfu Bu, Daniel H. C. Wan, Jianuo Chen, Emanuele Magliocca, Feng Ryan Wang, Alexander J.E. Rettie, Patrick S. Grant, Paul R. Shearing, Rhodri Jervis, Thomas S. Miller   +15 more
wiley   +1 more source