Results 1 to 10 of about 333,691 (218)

Does the CDC Surgical Wound Classification adequately predict postoperative infection in lower extremity fracture surgery? [PDF]

OTA Int
Cho E, House H, Marten A, Feffer M, Agel J, Scolaro J, Marmor M, Levack AE.   +7 more
europepmc   +2 more sources

Preclinical evaluation of a commercially available biofilm disrupting wound lavage for musculoskeletal trauma

Journal of Orthopaedic Surgery and Research, 2022
Background Treatment of open fractures remains a significant challenge in trauma care as these fractures are accompanied by extensive soft tissue damage, exposing the wound site to contaminants and increasing infection risk.
Michael E. Whitely, Sarah M. Helms, Preeti J. Muire, Alicia L. Lofgren, Rebecca A. Lopez, Joseph C. Wenke   +5 more
doaj   +1 more source

FK506 increases susceptibility to musculoskeletal infection in a rodent model

BMC Musculoskeletal Disorders, 2022
Background Delayed fracture healing caused by soft tissue loss can be resolved by the administration of a Th1 immunosuppressant, such as FK506. Additionally, open fractures are at high risk for infection.
Stefanie M. Shiels, Preeti J. Muire, Joseph C. Wenke   +2 more
doaj   +1 more source

Neutralization of HMGB1 improves fracture healing and γδ T lymphocyte counts at the fracture site in a polytrauma rat model

Journal of Experimental Orthopaedics, 2022
Purpose Delayed fracture healing is a common consequence of polytrauma (PT) occurring in patients with multiple injuries. We believe that when early release of high mobility group box 1 (HMGB1) molecules from necrotic tissues exceed their normal levels ...
Preeti J. Muire, Joshua J. Avila, Alicia L. Lofgren, Joseph C. Wenke   +3 more
doaj   +1 more source

Effect of valproic acid upon skeletal muscle subjected to prolonged tourniquet application

Trauma Surgery & Acute Care Open, 2023
Background Valproic acid (VPA), a histone deacetylase inhibitor, has shown improved outcomes when used as a pharmaceutical intervention in animal studies of hemorrhage, septic shock, and combined injuries.
Robert Moritz, Lee Mangum, Chet Voelker, Gerardo Garcia, Joseph Wenke   +4 more
doaj   +1 more source

Fracture healing in a polytrauma rat model is influenced by mtDNA:cGAS complex mediated pro‐inflammation

Journal of Experimental Orthopaedics, 2023
Purpose The mitochondrial DNA (mtDNA) activated cyclic guanosine monophosphate–adenosine monophosphate synthase—stimulator of interferon genes (cGAS‐STING) signaling pathway is a key player in mediating immune responses in autoimmune disorders and cancer.
Preeti J. Muire, Alicia L. Lofgren, Stefanie M. Shiels, Joseph C. Wenke   +3 more
doaj   +1 more source

Changes in the length and area of congenital nevi involving the face and extremities after two serial excisions [PDF]

Archives of Aesthetic Plastic Surgery, 2021
Background The objective of this study was to determine the outcome of serial excisions of congenital nevi involving the face and extremities and to calculate changes in the area and length of the nevi.
Jae Il Choi, Daegu Son
doaj   +1 more source

A Soft Skin Adhesive (SSA) Patch for Extended Release of Pirfenidone in Burn Wounds

Pharmaceutics, 2023
As much as half or more of deep partial-thickness burn wounds develop hypertrophic scarring and contracture. Once formed, treatments are only minimally effective.
Eugene P. Chung, Jesse Q. Nguyen, Tobias Tellkamp-Schehr, Katja Goebel, Anita Ollek, Cliff Krein, Adrienne R. Wells, Eliza A. Sebastian, Anja Goebel, Svenja Niese, Kai P. Leung   +10 more
doaj   +1 more source

Pseudomonas aeruginosa transcriptome adaptations from colonization to biofilm infection of skin wounds

Scientific Reports, 2021
In burn patients Pseudomonas aeruginosa infection is a major cause of morbidity. Analysis of the pathogen’s gene expression as it transitions from colonization to acute and then biofilm wound infection may provide strategies for infection control. Toward
Peter D’Arpa, S. L. Rajasekhar Karna, Tsute Chen, Kai P. Leung   +3 more
doaj   +1 more source

Systemic T Cell Exhaustion Dynamics Is Linked to Early High Mobility Group Box Protein 1 (HMGB1) Driven Hyper-Inflammation in a Polytrauma Rat Model

Cells, 2021
We previously reported an early surge in high mobility group box protein 1 (HMGB1) levels in a polytrauma (PT) rat model. This study investigates the association of HMGB1 levels in mediating PT associated dysregulated immune responses and its influence ...
Preeti J. Muire, Martin G. Schwacha, Joseph C. Wenke   +2 more
doaj   +1 more source