Results 131 to 140 of about 133,335 (273)
Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon +12 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela +13 more
wiley +1 more source
End-to-End Deep-Learning-Based Surrogate Modeling for Supersonic Airfoil Shape Optimization
AerospaceAerodynamic shape design optimization faces challenges due to the computational demands and the vast design space, limiting its practicality and scalability.
Diogo Pereira +2 more
doaj +1 more source
A framework for surrogate-based aerodynamic optimization
, 2011 At DLR, an optimization framework combining different CFD solvers, Design of Experiment methods, optimization algorithms, and various surrogate modeling methodologies with sample refinement strategies for efficient surrogate-based global optimization is under development. Several Kriging predictors are used because of their ability to approximate multi-
Li, Chunna +2 more
openaire +1 more source
Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer +14 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective People with epilepsy (PWE) may experience cognitive deficits but fail to undergo formal evaluation. This study compares cognitive status between PWE and healthy controls in the West African Republic of Guinea. Methods A cross‐sectional, case–control study was conducted in sequential recruitment phases (July 2024–July 2025) at Ignace ...
Maya L. Mastick +14 more
wiley +1 more source
Surrogate Based Evolutionary Algorithm For Design Optimization
, 2007 {"references": ["A. Ratle.., \"Accelerating the convergence of evolutionary algorithms by\nfitness landscape approximation\", Parallel Problem Solving from\nNature-PPSN V, Springer-Verlag, pp. 87-96, 1998.", "A. Smola and B. Sch\u00f6lkopf, \"A Tutorial on Support Vector Regression\",\nNeuroCOLT Technical Report NC-TR-98-030, Royal Holloway\nCollege ...
openaire +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin +11 more
wiley +1 more source
한국해양공학회지The fairlead chain stopper (FCS) is a newly developed detachable mooring system designed for installation on a floating offshore wind turbine. In this study, a discrete design optimization of the FCS was conducted using various surrogate models combined ...
Min-Seok Cheong, Chang-Yong Song
doaj +1 more source
Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein +13 more
wiley +1 more source