Results 121 to 130 of about 364,351 (266)

Surrogate resilience and clinical titration of presence in the open intensive care unit: a systematic narrative synthesis. [PDF]

Int J Nurs Stud Adv
Bahramifar A, Vahedian-Azimi A.
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Sparse polynomial surrogates for F-actin networks with compliant crosslinkers. [PDF]

Biomech Model Mechanobiol
Pacheco L, Parente M, Ferreira J.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Looking for a Cultured Surrogate for Effectome Studies of the Clubroot Pathogen

Frontiers in Microbiology, 2021
Melaine González-García, Edel Pérez-López, Edel Pérez-López, Edel Pérez-López, Edel Pérez-López   +4 more
doaj   +1 more source

Neural Surrogate-Enhanced Metaheuristic Optimization for Distributed Quadrotor Swarm Control. [PDF]

Sensors (Basel)
Li J, Wen Z, Ning Z.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Relationship between decision regret, anxiety, and depression in surrogate decision-makers for neurocritical patients with prolonged disorders of consciousness: a cross-lagged analysis. [PDF]

BMC Psychol
Zhang X, Mao S, Wang S, Yu J, Li R, Zhang Z, Chen Y, Zeng L.   +7 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Reply to Arnold et al.: More than words? Defining best practices in assessing surrogate understanding. [PDF]

ATS Sch
Pecanac KE, Golden BP.
europepmc   +1 more source