Results 151 to 160 of about 813,266 (291)

Reduce computational time: surrogate modeling and surrogate-based optimisation [PDF]

, 2012
Dhaene, Tom, Ulaganathan, Selvakumar
core  

The dominance of large-scale phase dynamics in human cortex, from delta to gamma. [PDF]

Elife
Alexander DM, Dugué L.
europepmc   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Learning to simulate realistic human diffuse reflectance spectra. [PDF]

J Biomed Opt
Hübner M, Bin Qasim A, Studier-Fischer A, Rees M, Tran Ba V, Nölke JH, Seidlitz S, Sellner J, Heinecke J, Brandt J, Özdemir B, Dreher K, Seitel A, Nickel F, Max Haney C, Kowalewski KF, Ayala L, Maier-Hein L.   +17 more
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Addressing clinical uncertainties in ATMP reimbursement: a review of methodological guidelines and European practice. [PDF]

Front Pharmacol
Delemarre L, Huys I, Van Dyck W, Simoens S.   +3 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Correcting model error bias in estimations of neuronal dynamics from time series observations. [PDF]

Sci Rep
Williams I, Taylor JD, Nogaret A.
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Wombs for rent: Exploring the motivations behind Ghanaian Women's decisions to become surrogate mothers. [PDF]

PLoS One
Boafo IM, Amarteifio DA, Tetteh PM, Hiadzi RA.   +3 more
europepmc   +1 more source