Results 51 to 60 of about 456,731 (293)
Universal Prediction Distribution for Surrogate Models [PDF]
SIAM/ASA Journal on Uncertainty Quantification, 2017 The use of surrogate models instead of computationally expensive simulation codes is very convenient in engineering. Roughly speaking, there are two kinds of surrogate models: the deterministic and the probabilistic ones. These last are generally based on Gaussian assumptions.
Ben Salem, Malek +3 more
openaire +5 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Computational Optimisation of Urban Design Models: A Systematic Literature Review
Urban ScienceThe densification of urban spaces globally has contributed to a need for design tools supporting the planning of more sustainable, efficient, and liveable cities.
JingZhi Tay +3 more
doaj +1 more source
BayCANN: Streamlining Bayesian Calibration With Artificial Neural Network Metamodeling
Frontiers in Physiology, 2021 Purpose: Bayesian calibration is generally superior to standard direct-search algorithms in that it estimates the full joint posterior distribution of the calibrated parameters.
Hawre Jalal +2 more
doaj +1 more source
Towards efficient multiobjective optimization: multiobjective statistical criterions [PDF]
, 2012 The use of Surrogate Based Optimization (SBO) is widely spread in engineering design to reduce the number of computational expensive simulations. However, "real-world" problems often consist of multiple, conflicting objectives leading to a set of ...
Couckuyt, Ivo +2 more
core +2 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Applied SciencesMeniscal root repair is not routinely recommended for patients over 75 years old, yet surrogate age-unrestricted human or porcine models are used for its evaluation.
Alejandro Peña-Trabalon +4 more
doaj +1 more source
On a novel approach for optimizing composite materials panel using surrogate models [PDF]
, 2011 This paper describes an optimization procedure to design thermoplastic composite panels under axial compressive load conditions. Minimum weight is the goal. The panel design is subject to buckling constraints.
Akcay-Perdahcioglu, D. +3 more
core +1 more source
Large scale variable fidelity surrogate modeling [PDF]
Annals of Mathematics and Artificial Intelligence, 2017 Engineers widely use Gaussian process regression framework to construct surrogate models aimed to replace computationally expensive physical models while exploring design space. Thanks to Gaussian process properties we can use both samples generated by a high fidelity function (an expensive and accurate representation of a physical phenomenon) and a ...
A. Zaytsev, E. Burnaev
openaire +2 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source