Results 51 to 60 of about 217,450 (265)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Data-Driven Multi-Objective Optimization of Conformal Cooling Channels for Energy-Efficient Injection Molding

Mathematics
Injection molding is widely used for plastic parts, but its performance is limited by the cooling stage, which dominates cycle time and affects dimensional stability and energy consumption.
Carlos Pereira, António J. Pontes, António Gaspar-Cunha   +2 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Intelligent Digital Rock Physics: Advances and Perspectives from Imaging Reconstruction to Pore-Scale Multiphase Flow Simulation

Applied Sciences
In characterizing unconventional reservoirs, conventional Digital Rock Physics (DRP) has long been constrained by three fundamental bottlenecks: the trade-off between imaging resolution and field of view, challenges in reconstructing multiscale pore ...
Xue Li, Lin Zhu, Feng Gao, Xin Liang, Zhengzheng Cao   +4 more
doaj   +1 more source

Reusable surrogate models for distillation columns

Computers & Chemical Engineering
Surrogate modeling is a powerful methodology in chemical process engineering, frequently employed to accelerate optimization tasks where traditional flowsheet simulators are computationally prohibitive. However, the state-of-the-art is dominated by surrogate models trained for a narrow range of fixed chemical systems and operating conditions, limiting ...
Martin Bubel, Tobias Seidel, Michael Bortz   +2 more
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

ANN-Based Surrogate Modeling for Seismic Fragility Assessment of Double-Layer Barrel Vault Roofs Supported by Double-Layer Latticed Walls

Infrastructures
Double-layer barrel vault roofs with double-layer vertical walls are widely used in important public buildings because of their high structural efficiency, favorable stiffness-to-weight ratio, and architectural versatility.
Mohammad Kheirollahi, Moein Mirzaei, Seyed Amir Banimahd, Shaghayegh Karimzadeh, Nuno Mendes, Paulo B. Lourenço   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

ML-Surrogate Model

This repository contains attachments related to the publication:**[Machine Learning Surrogate Optimization Framework for an Additively Manufactured, Linearly Polarized Metal Coaxial-to-Circular Waveguide Transition for Space Applications] ****Published in: ** [Engineering Applications of AI], [Volume xxx], [Issue yyy], [Year 2025], [Page Numbers zzz or
HASAN, MUHAMMAD FAHAD, Huang, He, Mushtaq, Ray Tahir   +2 more
  +4 more sources