Results 31 to 40 of about 18,445 (350)
Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma
Pediatric Blood &Cancer, EarlyView.ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack +12 more
wiley +1 more source
Reproductive technologies as social innovations in the system of public health [PDF]
Экономика региона, 2014 The article is devoted to such important problem as Russians’ reproductive health worsening that defines health of posterity and viability of generations, and appreciably impacts on the birth rate. Statistics of contraception among women of reproductive
Raisa Viktorovna Nifantova +1 more
doaj +1 more source
From modern workplaces to modern families – re-envisioning the work–family conflict [PDF]
, 2014 The Modern Workplaces Consultation 2011 set the foundations for the current revisions to work–family rights in the UK. They are underpinned by a desire to make modern workplaces more flexible and responsive to the needs of working families.
Weldon-Johns, Michelle
core +2 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Revista Iberoamericana de Bioética, 2018 This paper analyzes the personality rights of the pregnant woman in surrogate motherhood: specifically, the right to physical and mental integrity and the right to personal data protection and habeas data.
Aránzazu Bartolomé Tutor
doaj +1 more source
Surrogacy with cross-border effects: Reality and law [PDF]
Zbornik Radova: Pravni Fakultet u Novom Sadu, 2012 This paper analyzes a topic which is highly ranked in law reviews throughout the world, due to the fact that gestational surrogate motherhood as a fact of life is subjected to very different legal regulation worldwide.
Bordaš Bernadet
doaj +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
About the child’s right to establish its origins on the mother’s part
Acta Universitatis Lodziensis Folia Iuridica, 2019 This text is about the child’s right to determine its genetic origin in the field of establishing motherhood, also in relation to the problem of medically assisted procreation techniques and the so-called ‘surrogate motherhood’.
Magdalena Sobas
doaj +1 more source
FEBS Open Bio, EarlyView.The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source
Surrogacy relationships: a critical interpretative review [PDF]
, 2020 Based on a critical interpretative review of existing qualitative research investigating accounts of ‘lived experience’ of surrogates and intended parents from a relational perspective, this article proposes a typology of surrogacy arrangements.
Korolczuk, Elzbieta +2 more
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