Results 181 to 190 of about 480,494 (299)

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

open access: yesAdvanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong   +24 more
wiley   +1 more source

Bioinspired Adaptive Leg‐Claw Enables Robust Perching and Grasping for UAVs

open access: yesAdvanced Science, EarlyView.
Inspired by owl limb morphology and bat roosting behavior, this study presents a bioinspired adaptive leg‐claw mechanism that enables UAVs to perform robust and versatile perching and grasping. The design integrates a four‐link tibial structure, tension‐driven deformable feet, and active control, enabling stable perching on various branches and ...
Tianyu Cheng   +6 more
wiley   +1 more source

A Soft Matrix Microenvironment Promotes Laterally Spreading Tumors via Oxidative Phosphorylation‐Dependent Cell Adhesion

open access: yesAdvanced Science, EarlyView.
Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong   +21 more
wiley   +1 more source

Millimeter‐Scale Dual‐Opposing RNA‐Gradient Hydrogel for Interfacial Gene Silencing

open access: yesAdvanced Science, EarlyView.
A branched microfluidic platform enables the fabrication of millimeter‐scale hydrogels with dual‐opposing RNA‐gradients for precise spatial control of cell gene expression. This device allows for the generation of multiple constructs at once, offering potential for future engineering of complex tissue interfaces with improved physiological relevance ...
Tyler Hoffman   +11 more
wiley   +1 more source

Engineering an Optogenetic pH‐Modulator in Bacteria

open access: yesAdvanced Science, EarlyView.
ABSTRACT Cells in many naturally occurring organisms routinely cooperate to control their extracellular pH in a dynamic and reversible manner, but this capability has been underexplored in synthetic biology. Here, we sought to engineer a microbial system that switches between two states —high and low extracellular pH— with minimal human intervention ...
Jenevieve Kuang   +7 more
wiley   +1 more source

Magnetoelectric Nanoparticle‐Based Wireless Brain–Computer Interface: Underlying Physics and Projected Technology Pathway

open access: yesAdvanced Science, EarlyView.
Magnetoelectric nanoparticles (MENPs) enable fully wireless, minutely invasive neuromodulation, and potentially neural recording, by converting magnetic into electric and, conversely, electric into magnetic fields, respectively, at high spatiotemporal resolution.
Elric Zhang   +14 more
wiley   +1 more source

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