Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
How does agricultural insurance affect income inequality within farmers? Based on survey data from Shandong Province, China. [PDF]
PLoS OneShe Z, Sun L, Yuan Y, Chen S.
europepmc +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Trends and determinants of early neonatal mortality in Ethiopia: evidence from the Ethiopian demographic and health survey data. [PDF]
BMC PediatrTebeje TM +10 more
europepmc +1 more source
Micronutrient Deficiency and Nutritional Status Among Indonesian Children Under Five Years of Age: Evidence from National Survey Data. [PDF]
NutrientsErnawati F +14 more
europepmc +1 more source
Concordance of coverage estimates from routine and survey data of measles second dose vaccine in Western Kenya. [PDF]
Front EpidemiolMoturi AK +5 more
europepmc +1 more source
Child and youth chronic physical health conditions: a comparison of survey data and linked administrative health data in Ontario. [PDF]
BMC PediatrGolden G, Wang L, Reid GJ.
europepmc +1 more source
Survey Data on Attitudes Towards Foreign Aid & Development in France, Germany, Great Britain, and the U.S. [PDF]
Sci DataTorres-Raposo F +4 more
europepmc +1 more source