Results 201 to 210 of about 3,324,864 (354)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The Critically Endangered Haitian endemic palm Attalea crassispatha (Arecaceae) and its living collections in Fairchild Tropical Botanic Garden: Perspectives from conservation surveys and DNA microsatellite (SSR) data

, 2023
Brett Jestrow, Michael Hass, William Cinea, Alan R. Franck, Joël Timyan, M. Patrick Griffith, Javier Francisco‐Ortega   +6 more
openalex   +2 more sources

The PELFISH surveys : objectives and data collection

, 1997
From 1991 to 1995, twenty acoustic surveys took place in the Java Sea and the surrounding areas in the frame of the PELFISH Project, sponsored by the European Union, Indonesia and France. Their aim was to study the distribution, abundance and behaviour of the pelagic fauna, especially on the fishing grounds of the seiners.
Petit, Didier, Cotel, Pascal, Nugroho, D.   +2 more
openaire   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Implementing remote data collection methods in an address-based probability sample for a population-based sexual health survey (Britain’s fourth National Survey of Sexual Attitudes and Lifestyles, Natsal-4)

Soazig Clifton, Anne Conolly, Katharine Sadler, Rebecca Light, Nigel Field, Pam Sonnenberg, Catherine H Mercer   +6 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Should the Workload of Combining Clinical Practice With Data Collection be Considered: A Survey of Physicians With Data Collection Experience. [PDF]

J Evid Based Med
Zhang X, Jiang Y, Guan Z, Zhao M, Hu M, Xu Q, Wang W, Gao W, Qiu R, Li M, Yang B, Zhou L, Liu Z, Li Z, Xiang Y, Zhao J, Wang Z, Lou X, Guo S, Dai G, Bian Z, Wang H, Zhao C, Shang H.   +23 more
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Novel way of displaying Delphi responses when collecting through the REDCap data collection system. [PDF]

Trials
Barber VS, Calvert C, Appelbe DE.
europepmc   +1 more source

A Review of Survey Data-Collection Modes:

, 2015
Tom W. Smith, Jibum Kim
openalex   +2 more sources