Results 131 to 140 of about 89,205 (311)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Review of Survey activities 2016: Inversion structures as potential petroleum exploration targets on Nuussuaq and northern Disko, onshore West Greenland, Electronic Supplement Fig. ES1 [PDF]

Geological Survey of Denmark and Greenland Bulletin, 2017
E.V. Sørensen, J.R. Hopper, G.K. Pedersen, H. Nøhr-Hansen, P. Guarnieri, A.K. Pedersen, F.G. Christiansen   +6 more
doaj  

Understanding inclusion, diversity, equity, and accessibility in a distributed data network: environmental scan within health data research network Canada. [PDF]

Int J Popul Data Sci
Freier A, Bowler L, Owczar H, Gogovor A, Pandy M, Riley J, Stirling M, Duris J, McGrail K, Nickel NC.   +9 more
europepmc   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Review of Survey activities 2015: The Greenland Mineral Resources Portal – another step forward [PDF]

Geological Survey of Denmark and Greenland Bulletin, 2016
M. Pedersen, M. Hansen, B.H. Heincke , L. Thorning   +3 more
doaj  

Assessing Cultural, Religious, and Spiritual Confidence and Perceived Preparedness in Community Palliative and End-of-Life Care: A Service Evaluation. [PDF]

Healthcare (Basel)
Islam Z, Horne F.
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Review of Survey activities 2015: Regional climate-model performance in Greenland firn derived from in situ observations [PDF]

Geological Survey of Denmark and Greenland Bulletin, 2016
C. Charalampidis, D. van As, P.L. Langen, R.S. Fausto, B. Vandecrux , J.E. Box   +5 more
doaj  

Family or caregiver outcomes after critical illness (FOCUS): a protocol for a core outcome set development study. [PDF]

BMJ Open
Brown C, Hartley P, Malyon A, Connolly B, Lone NI, McPeake J.   +5 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source