Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Forum: Qualitative Social Research, 2004 This book consists of 26 articles and introduces the reader to different fields, methods and aspects of life course and generation research. It is published on the occasion of Martin KOHLI's 60th birthday and focuses on his research program.
Stefanie Große
doaj
Retirement Research Using the Health and Retirement Survey [PDF]
This paper highlights unanswered research questions in the economics of retirement, and shows how these issues can be addressed using the new Health and Retirement Survey (HRS). Unique features of the survey are described including administrative records
Alan L. Gustman +2 more
core
An example of implementing a safety protocol in remote intervention and survey research with college students. [PDF]
Clin Trials, 2023 Mehus CJ +5 more
europepmc +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Survey research of patient's preference on choosing microscopic or endoscopic spine surgery for lumbar discectomy. [PDF]
PLoS One, 2023 Keorochana G +7 more
europepmc +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Access to Health Information in the Polish Healthcare System-Survey Research. [PDF]
Int J Environ Res Public Health, 2022 Pilarska A +2 more
europepmc +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Gender disparity in STEM education: a survey research on girl participants in World Robot Olympiad. [PDF]
Int J Technol Des Educ, 2023 Chiang FK, Tang Z, Zhu D, Bao X.
europepmc +1 more source