Results 141 to 150 of about 6,171,383 (360)

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Household water security is a mediator of household food security in a nationally representative sample of Mexico

open access: yesPublic Health Nutrition
Objective: Explore the relationship between water insecurity (WI) and food security and their covariates in Mexican households. Design: A cross-sectional study with nationally representative data from the National Health and Nutrition Survey-Continuous
Teresa Shamah-Levy   +5 more
doaj   +1 more source

Arctic Ocean 1957

open access: yes, 1957
Depths shown by isolines.; Includes inset map.; "Compiled by Chief Cartographer, Surveys and Mapping Branch, Dept. of Mines & Technical Surveys for Defence Resource Board of Canada, Ottawa, 1957" -- stamped.; Accompanied by 2 sheets of text from E.R ...

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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Eastern Choiseul [cartographic material] : geological sketch map /

open access: yes, 1959
Map of Choiseul, showing geological features. Relief shown by hachures.; "Printed for D.O.S. by the Ordnance Survey".; "From material supplied by Dr. P.J.
Great Britain. Directorate of Overseas Surveys.
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

State of HIV costing in Latin America and the Caribbean: a systematic literature review

open access: yesRevista Panamericana de Salud Pública
Objectives. To summarize available data on unit costs for human immunodeficiency virus (HIV) testing, prevention, and care interventions in Latin America and the Caribbean. Methods. We conducted a systematic literature review of costing studies published
Diego Cerecero-García   +3 more
doaj   +1 more source

Fiji, Vanua Levu [cartographic material].

open access: yes, 1960
Relief shown by gradient tints.; Map of Vanua Levu showing towns, villages, roads, airports, government administration offices, boundaries, sugarmills, agricultural and forest stations.; Also available online http://nla.gov.au/nla.map ...
Great Britain. Directorate of Overseas Surveys.
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