Results 171 to 180 of about 8,364,634 (343)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Persistent Burden of Severe Hypoglycemia and Impaired Awareness of Hypoglycemia Among People With Type 1 Diabetes Despite Technology Use: A Follow-up Survey. [PDF]

Diabetes Care
Sherr JL, Molinsky RL, Pakalapati T, Sherwood JS, Peter ME, Cornelius EM, Pettus J.   +6 more
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Observations of extreme dehydration and rehydration leading to recovery of a threatened California tiger salamander

California Fish and Wildlife Journal, 2022
Zachary A. Cava, Kyla M. Garten, Sarah M. Foster, Jeff A. Alvarez   +3 more
doaj   +1 more source

Quality of life during electronic patient-reported outcome (ePRO) monitoring in thoracic surgery patients: a pilot randomized controlled trial. [PDF]

Qual Life Res
Cox CE, Deal AM, Wang M, Williams B, Gentry AL, Hoch C, Schlusser C, Shrestha S, Boisson-Walsh A, Kurz C, Happ M, Bright A, Hill L, Coleman J, Long J, Haithcock B, Bennett AV, Basch E, Mody GN.   +18 more
europepmc   +1 more source

Mental disorders among college students in the World Health Organization World Mental Health Surveys

Psychological Medicine, 2016
R. P. Auerbach, J. Alonso, W. Axinn, P. Cuijpers, D. Ebert, J. G. Green, I. Hwang, R. Kessler, H. Liu, P. Mortier, M. Nock, S. Pinder-Amaker, N. Sampson, S. Aguilar-Gaxiola, A. Al-Hamzawi, L. Andrade, C. Benjet, J. Caldas-de-Almeida, K. Demyttenaere, S. Florescu, G. de Girolamo, O. Gureje, J. Haro, E. Karam, A. Kiejna, V. Kovess-Masfety, S. Lee, J. Mcgrath, Siobhan O'Neill, B. Pennell, K. Scott, M. ten Have, Y. Torres, A. Zaslavsky, Z. Zarkov, R. Bruffaerts   +35 more
semanticscholar   +1 more source

Trauma Survey [PDF]

Academic Psychiatry, 2019
openaire   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Childhood adversities and adult psychopathology in the WHO World Mental Health Surveys

British Journal of Psychiatry, 2010
R. Kessler, K. McLaughlin, J. Green, M. Gruber, N. Sampson, A. Zaslavsky, S. Aguilar-Gaxiola, A. Alhamzawi, J. Alonso, M. Angermeyer, C. Benjet, E. Bromet, S. Chatterji, G. Girolamo, K. Demyttenaere, J. Fayyad, S. Florescu, G. Gal, O. Gureje, J. Haro, Chi‐yi Hu, E. Karam, N. Kawakami, Sing Lee, J. Lépine, J. Ormel, J. Posada-Villa, R. Sagar, A. Tsang, Bedirhan Üstün, S. Vassilev, M. Viana, Daniel R. Williams   +32 more
semanticscholar   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source