Results 301 to 310 of about 8,868,074 (395)

Surveys to substantiate elimination of trachoma as a public health problem in the Republic of the Union of Myanmar. [PDF]

Int Health
Wynn MMM, Win Y, Lin Y, Win SS, Badri T, Mohamed J, Zaw L, Solomon AW, Dejene M, Mpyet C, Adamu Y, Abateneh A, Shafi M, Jimenez C, Bakhtiari A, Boyd S, Harte A, Harding-Esch EM, Ngondi JM.   +18 more
europepmc   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Key incidents identified by the Royal College of Pathologists of Australasia Quality Assurance Programs Key Incident Monitoring and Management EQA program. [PDF]

Biochem Med (Zagreb)
Jayanetti A, Roxby D, Badrick T.
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

A Trauma-informed Care Curriculum for Perinatal Providers, Staff, and Learners. [PDF]

MedEdPORTAL
Chin J, Sheth M, Britz S, Owens L, Zhang Y.   +4 more
europepmc   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Establishing foundations: Designing a long-term experiment to evaluate whether nestboxes assist population recovery of an endangered species after fire. [PDF]

PLoS One
Ridley JCH, Youngentob KN, Marsh K, Evans MJ, Lavery T, Ashman K, Gracanin A, Lindenmayer D.   +7 more
europepmc   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Achieving elimination of soil-transmitted helminthiasis as a public health problem in Mali. [PDF]

BMJ Glob Health
Traore M, Maiga FK, Keita M, Guindo B, Sacko M, Doumbia SS, Doumbia MN, Dembele B, Coulibaly YI, Stern C, Reid S, Serna A, Fleming FM, Weaver AM, Zhang Y.   +14 more
europepmc   +1 more source

Continuous Glucose Monitoring in the Management of Congenital Hyperinsulinism: A National User-satisfaction Survey, UK.

J Clin Endocrinol Metab
Couch H, Pearson A, Malhotra N, Ferguson M, Couch G, Gilbert C, Morgan K, Mann S, Cassidy K, Worthington S, O'Shea E, SalomonEstebanez M, Worth C, Senniappan S, Banerjee I, Dastamani A.   +15 more
europepmc   +1 more source