Results 281 to 290 of about 9,160,314 (400)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Adoption of new IUCN resolution guiding the conservation of amphibians

Oryx
Amaël Borzée, Sally Wren, Caroline Lees, Gina della togna, Janice Chanson, Jonathan Wilcken, Louise Hobin, Pria N. Ghosh, Simon N. Stuart   +8 more
doaj   +1 more source

Impact of treatment modality on survival in FIGO stage IIB cervical cancer: a population-based propensity-score matched analysis. [PDF]

Sci Rep
Tu H, Liu G, Gu H, Liu Z, Huang H, Liu J.   +5 more
europepmc   +1 more source

Limited ATF4 Expression in Degenerating Retinas with Ongoing ER Stress Promotes Photoreceptor Survival in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa

, 2016
Yogesh Bhootada, Pravallika Kotla, Sergei Zolotukhin, Oleg S. Gorbatyuk, Zsuzsanna Bebök, Mohammad Athar, Marina S. Gorbatyuk   +6 more
openalex   +2 more sources

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

An IUCN Species Survival Commission Center for Species Survival on Behaviour Change

Oryx
João Neves, Isa Pinho, Edgar Ribeiro
doaj   +1 more source

A phase II study of trifluridine/tipiracil in combination with ramucirumab in advanced, refractory gastric, or gastroesophageal junction adenocarcinomas. [PDF]

Oncologist
Kim DW, Kim RD, Jimenez MM, Kim Y, Mehta R.   +4 more
europepmc   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Machine Learning-Based Survival Analysis for Patients Receiving Lenvatinib for Unresectable Hepatocellular Carcinoma. [PDF]

J Hepatocell Carcinoma
Lu CH, Chang CW, Chen SC, Kao WY, Ting WY, Lu CH, Chuang KI, Ni CF, Hsieh YY, Wu MS, Su CW, Chang CC, Wu CH.   +12 more
europepmc   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source