Results 51 to 60 of about 1,623,179 (299)
Constructing stage-structured matrix population models from life tables: comparison of methods [PDF]
PeerJ, 2017 A matrix population model is a convenient tool for summarizing per capita survival and reproduction rates (collectively vital rates) of a population and can be used for calculating an asymptotic finite population growth rate (λ) and generation time ...
Masami Fujiwara, Jasmin Diaz-Lopez
doaj +2 more sources
A discrete-time survival model for porcine epidemic diarrhea virus
Transboundary and Emerging Diseases, 2022 Abstract Since the arrival of porcine epidemic diarrhea virus (PEDV) in the United States in 2013, elimination and control programs have had partial success. The dynamics of its spread are hard to quantify, though previous work has shown that local transmission and the transfer of pigs within production systems are most associated with ...
Parker Trostle +3 more
openaire +2 more sources
Non-standard discretization of biological models [PDF]
, 2015 We consider certain types of discretization schemes for differential equations with quadratic nonlinearities, which were introduced by Kahan, and considered in a broader setting by Mickens.
Towler, Kim, Hone, Andrew N.W.
core
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Integrated Multi-omics Survival Analysis of Gynecologic and Breast Cancers [PDF]
, 2023 openThis study utilized a multi-omics approach, incorporating gene expression, methylation, copy number variation, and mutation data, to analyze the survival of patients with Breast Carcinoma and Gynecologic Cancers (Ovarian Serous Cystadenocarcinoma ...
ZOLFAGHARI, AMIN
core
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Derivation of an adjoint consistent discontinuous Galerkin discretization of the compressible Euler equations [PDF]
, 2006 Adjoint consistency - in addition to consistency - is the key requirement for discontinuous Galerkin (DG) discretizations to be of optimal order in L2 as well as measured in terms of target functionals.
Hartmann, Ralf
core
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source