Neurotrophic requirements of human motor neurons defined using amplified and purified stem cell-derived cultures. [PDF]
PLoS ONE, 2014 Human motor neurons derived from embryonic and induced pluripotent stem cells (hESCs and hiPSCs) are a potentially important tool for studying motor neuron survival and pathological cell death.
Nuno Jorge Lamas +6 more
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Survival Motor Neuron (SMN) Protein Insufficiency Exacerbates Renal Ischemia/Reperfusion Injury [PDF]
Frontiers in Physiology, 2019 The survival of motor neuron (SMN) protein is ubiquitously involved in spliceosome assembly and ribonucleoprotein biogenesis. SMN protein is expressed in kidney and can affect cell death processes. However, the role of SMN in acute kidney injury (AKI) is
Xiaoqian Qian +7 more
doaj +3 more sources
Fluorescence Correlation Spectroscopy Reveals Survival Motor Neuron Oligomerization but No Active Transport in Motor Axons of a Zebrafish Model for Spinal Muscular Atrophy [PDF]
Frontiers in Cell and Developmental Biology, 2021 Spinal Muscular Atrophy (SMA) is a progressive neurodegenerative disease affecting lower motor neurons that is caused by a deficiency in ubiquitously expressed Survival Motor Neuron (SMN) protein.
Angela Koh +6 more
doaj +2 more sources
Bioenergetic status modulates motor neuron vulnerability and pathogenesis in a zebrafish model of spinal muscular atrophy. [PDF]
PLoS Genetics, 2017 Degeneration and loss of lower motor neurons is the major pathological hallmark of spinal muscular atrophy (SMA), resulting from low levels of ubiquitously-expressed survival motor neuron (SMN) protein.
Penelope J Boyd +16 more
doaj +7 more sources
Effects of Inhibitors of SLC9A-Type Sodium-Proton Exchangers on Survival Motor Neuron 2 (SMN2) mRNA Splicing and Expression. [PDF]
Mol Pharmacol, 2022 Kanda S, Moulton E, Butchbach MER.
europepmc +3 more sources
Extracellular vesicles from a muscle cell line (C2C12) enhance cell survival and neurite outgrowth of a motor neuron cell line (NSC-34) [PDF]
, 2014 Introduction: There is renewed interest in extracellular vesicles over the past decade or 2 after initially being thought of as simple cellular garbage cans to rid cells of unwanted components.
Christopher McGee +3 more
core +3 more sources
Regulation of Survival Motor Neuron Gene Expression by Calcium Signaling. [PDF]
Int J Mol Sci, 2021 Choi K +18 more
europepmc +3 more sources
Survival Motor Neuron Protein is Released from Cells in Exosomes: A Potential Biomarker for Spinal Muscular Atrophy. [PDF]
Sci Rep, 2017 Nash LA +11 more
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Decreased function of survival motor neuron protein impairs endocytic pathways. [PDF]
Proc Natl Acad Sci U S A, 2016 Dimitriadi M +12 more
europepmc +3 more sources
Dual SMN inducing therapies can rescue survival and motor unit function in symptomatic ∆7SMA mice
Neurobiology of Disease, 2021 Spinal muscular atrophy (SMA) is an autosomal recessive disease characterized by survival motor neuron (SMN) protein deficiency which results in motor neuron loss and muscle atrophy. SMA is caused by a mutation or deletion of the survival motor neuron 1 (
Kaitlyn M. Kray +4 more
doaj +1 more source