Results 311 to 320 of about 160,996 (342)
Some of the next articles are maybe not open access.
Survival motor neuron protein in the nucleolus of mammalian neurons
Brain Research, 2002Spinal muscular atrophy (SMA) is an inherited motor neuron disease caused by mutations in the survival motor neuron gene (SMN1). While it has been shown that the SMN protein is involved in spliceosome biogenesis and pre-mRNA splicing, there is increasing evidence indicating that SMN may also perform important functions in the nucleolus.
Karen A, Wehner +7 more
openaire +2 more sources
Motor neuron target selectivity and survival after prolonged axotomy [PDF]
Restorative Neurology and Neuroscience, 2013 Purpose: After a cut peripheral nerve is repaired, motor neurons usually regenerate across the lesion site, however they often enter an inappropriate Schwann cell tube and may be directed to an inappropriate target organ such as skin, resulting in continued loss of function.
Grant A, Robinson, Roger D, Madison
openaire +2 more sources
Post-translational modifications in the survival motor neuron protein
Biochemical and Biophysical Research Communications, 2004Spinal muscular atrophy (SMA) is an autosomal recessive disease characterized by a progressive loss of the spinal motoneurons. The SMA-determining gene has been termed survival motor neuron (SMN) and is deleted or mutated in over 98% of patients. The encoded gene product is a protein expressed as different isoforms.
LA BELLA, Vincenzo +2 more
openaire +3 more sources
Androgen Receptor Function in Motor Neuron Survival and Degeneration
Physical Medicine and Rehabilitation Clinics of North America, 2008Polyglutamine repeat expansion in the androgen receptor is responsible for the motor neuron degeneration in X-linked spinal and bulbar muscular atrophy (SBMA; Kennedy's disease). This mutation, like the other polyglutamine repeat expansions, has proven to be toxic itself by a gain-of-function effect; however, a growing body of evidence indicates that ...
Gregory A, Cary, Albert R, La Spada
openaire +2 more sources
p21ras supports the survival of chick embryonic motor neurones
NeuroReport, 1996Various trophic factors present in muscle extract can promote the survival of cultured motor neurones. However, little is known about the signal transduction pathways used in these cells. The proto-oncogene product p21ras has been shown to play an important role in proliferative and differentiative signalling pathways.
G, Weng +4 more
openaire +2 more sources
SR57746A: A survival factor for motor neurons in vivo
Journal of the Neurological Sciences, 1998SR57746A(1-[2-(naphth-2-yl)ethy]]-4-(3-trifluoromethyl phenyl)-1,2,5,6-tetrahydropyridine, hydrochloride) is a non-peptide compound which has been shown to exhibit a wide range of neurotrophic effects both in vitro and in vivo. Here we examine the ability of SR57746A on axotomized spinal motor neuron death in the developing rat spinal cord.
Y, Iwasaki +3 more
openaire +2 more sources
Survival motor neuron (SMN) protein
The Survival of Motoneuron (SMN) protein is well known to cause Spinal Muscular Atrophy (SMA) if not present in sufficient concetration inside the cell. To investigate the influence of phosphorylations on serine resiudes on protein stability, this master’s thesis aims to produce four different variants of the C-terminal section of the protein with ...openaire +1 more source
Riluzone may help survival in motor neurone disease
BMJ, 1994A French research team has reported a small gain in the understanding of amyotrophic lateral sclerosis. But although there was widespread news coverage about it in Europe and the United States, scientists remain sceptical. Amyotrophic lateral sclerosis affects upper motor neurones, and little more is known about it today than when it was first ...
openaire +1 more source
Cancer treatment and survivorship statistics, 2022
Ca-A Cancer Journal for Clinicians, 2022Kimberly D Miller +2 more
exaly