Results 201 to 210 of about 1,877,858 (304)

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Proposing preoperative neutrophil percentage-to-albumin ratio as an effective prognostic factor for postoperative prognosis of distal cholangiocarcinoma: a retrospective cohort study. [PDF]

Front Med (Lausanne)
Wang HX, Wang ZY, Lyu SC, Huang JC, He Q, Lang R, Jiang T.   +6 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Supramaximal Resection in Glioblastoma: Expanding Surgical Boundaries in the Era of Precision Neuro-Oncology-A Systematic Review. [PDF]

Cancers (Basel)
Harper SD, Perryman T, Carlson-Clarke B, Baisiwala S, Rogowski B, Carson A, Sharma I, Patel SG, Oduro ES, Delgadillo A, Sudhakar N, Youssef MI, Patel KS.   +12 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Prognostic Implications of Programmed Cell Death Ligand 1 Expression, Cluster of Differentiation 8-Positive T-Cell Infiltration, and Related Immunophenotypes in Invasive Mucinous Adenocarcinoma of the Lung: A Multicenter Study. [PDF]

MedComm (2020)
Zhang G, Zheng C, Jia J, Li X, Wang L, Zhang L, Zhang Y, Yue M, Zhang S, Liu Y, Xue L, Xue Q, He J.   +12 more
europepmc   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Efficiency of Immunological Blood Biomarkers in Predicting Chemotherapy Response and Survival Outcome for Non-Targetable Advanced Non-Small Cell Lung Cancer Patients. [PDF]

Lung Cancer (Auckl)
Lumjiaktase P, Kemawichanurat N, Santiwiwas K, Kuttiyod T, Oranratnachai S, Trachu N, Monnamo N, Khiewngam K, Simmalee K, Reungwetwattana T.   +9 more
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Predictive value of natural killer (NK) cells in bone marrow for relapse in diffuse large B cell lymphoma: integrating antibody-dependent cell-mediated cytotoxicity (ADCC)-based immunotherapy. [PDF]

Cancer Immunol Immunother
Rincón-López S, Atencio-Matos J, Pereda-Sainz O, Larreina-Pérez J, Campeny-Najara A, Esteban-Figuerola A, Hernandez-Perez M, Garrastachu-Zumaran P, Velasco-Ruiz M, García-Bosque I, Rodriguez-Lefler C, Ruiz de Gaona E, Feliu J, Cabello J, Martín-Carnicero A, García-Muñoz R.   +15 more
europepmc   +1 more source