Results 91 to 100 of about 1,834,040 (263)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Genetic and morphological factors of nephritic survival rate

RUDN Journal of Medicine, 2009
The present research is devoted studying of influence of genetic and morphological factors on nephritic survival rate. Interrelation VNTR of polymorphism IL-1Ra with the accelerated falling of function of kidneys is revealed.
M I Churnosov, A A Dolzhikov, E V Kalmykova, I K Aristova, V S Vaschilin, V G Nesterov   +5 more
doaj  

Effect of Magnetic Fields on the Development of the Larvae of the Jaguar Cichlid (Parachromis managuensis, Günther, 1867) and the Green Terror (Andinoacara rivulatus, Günther, 1860)

Animals
This article has examined the effects of magnetic fields with intensities of 1 mT, 3 mT, and 5 mT on two species of cichlid fish (family Cichlidae). This study focused specifically on assessing the influence of these magnetic fields on larval development,
Radosław Piesiewicz, Agata Korzelecka-Orkisz, Krzysztof Formicki   +2 more
doaj   +1 more source

Survival Rates in Bankruptcy Systems: Overlooking the Evidence

European Journal of Law and Economics, 2001
Extensive research on bankruptcy still has not made it possible to end the efficiency discussion concerning the need for a reorganization provision in bankruptcy laws. In this paper, I discuss the pervasiveness of asset sales in bankruptcy procedures and the effect it has on survival rates.
openaire   +4 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Most Significant Factors Affecting the Survival of Patients with Out-of-hospital Cardiac Arrest

Albanian Journal of Trauma and Emergency Surgery
Introduction: Cardiac arrest, the sudden loss of heart function, often strikes without warning. Immediate medical intervention is not only critical, but it is also a lifeline for these patients.
Isuf Bajrami, Avdyl Pacolli, Amire Dragusha, Haki Dragusha, Defrim Qerimi   +4 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Preliminary Research on Freeze-drying Preservation of Human Hepatoma Hep-G2 Cells

Zhileng xuebao, 2017
Freeze-drying is a long-term and effective method for cell preservation. The lyoprotectant can have a significant effect on cell freeze-drying. In this study, different volume concentrations of Me2SO, glycerol, and different mass concentrations ...
Song Ping, Li Weijie, Zhou Xinli, Liu Baolin   +3 more
doaj  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source