Results 131 to 140 of about 8,305,568 (307)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Annual Survival Rate Comparisons.
, 2016 Annual Survival Rate Comparisons.
Brant A. Schumaker (3092643) +7 more
core +1 more source
Genetic and morphological factors of nephritic survival rate
RUDN Journal of Medicine, 2009 The present research is devoted studying of influence of genetic and morphological factors on nephritic survival rate. Interrelation VNTR of polymorphism IL-1Ra with the accelerated falling of function of kidneys is revealed.
M I Churnosov +5 more
doaj
Most Significant Factors Affecting the Survival of Patients with Out-of-hospital Cardiac Arrest
Albanian Journal of Trauma and Emergency SurgeryIntroduction: Cardiac arrest, the sudden loss of heart function, often strikes without warning. Immediate medical intervention is not only critical, but it is also a lifeline for these patients.
Isuf Bajrami +4 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
The formula for survival in resuscitation
, 2013 : The International Liaison Committee on Resuscitation (ILCOR) Advisory Statement on Education and Resuscitation in 2003 included a hypothetical formula - 'the formula for survival' (FfS) - whereby three interactive factors, guideline quality (science ...
Soreide, Eldar +4 more
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Preliminary Research on Freeze-drying Preservation of Human Hepatoma Hep-G2 Cells
Zhileng xuebao, 2017 Freeze-drying is a long-term and effective method for cell preservation. The lyoprotectant can have a significant effect on cell freeze-drying. In this study, different volume concentrations of Me2SO, glycerol, and different mass concentrations ...
Song Ping +3 more
doaj