Results 151 to 160 of about 506,209 (297)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Ayduth Lachayim = Witness to life : Holocaust survivors in the Cleveland Jewish community : presented at the World Gathering of Jewish Holocaust Survivors, Israel, June 15-18, 1981

Accounts of varying length of the experiences of Holocaust survivors. Some accounts include pictures. Original pages include addresses and phone numbers of survivors; these have been redacted for display ...

core  

Navigating ICU Survival With a Temporary Tracheostomy. A Phenomenological Hermeneutic Study. [PDF]

Scand J Caring Sci
Akroute A, Brinchmann BS, Hovland A, Fredriksen STD.   +3 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Service responses to survivors of sexual violence : perspectives of National Health Service and voluntary sector professionals on inter-agency working with survivors [PDF]

The first chapter of this thesis critically reviews the existing literature on Restorative Justice (RJ) for crimes of sexual violence. It considers whether RJ has a contribution to make to the psychological wellbeing of survivors, provides clinicians ...
Bishop, Sarah M. (Researcher in clinical psychology)
core  

Ethnic Differences in Unmet Care Needs Among Cancer Survivors in Utah Using a Mixed Methods Approach. [PDF]

Cancer Med
Jackson SG, Kirchhoff AC, Edwards SL, Herget KA, Carter ME, Codden RR, Ofori-Atta BS, Nagata M, Sweeney C, Millar MM.   +9 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Health-Related Quality of Life, Comorbidities, and Lifestyle Behaviors Among Survivors of Obesity-Related and Non-Obesity-Related Cancer Types. [PDF]

Cancers (Basel)
Hernández W, Rodríguez-Ortiz G, González-Sepúlveda L, Pérez CM, Soto-Salgado M, Sánchez-Díaz CT.   +5 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Pre-frailty and frailty as independent predictors of mortality in U.S. breast cancer survivors: Evidence from the national health interview survey, 1997 to 2018: Frailty and all-cause mortality. [PDF]

Medicine (Baltimore)
Wu C, Du X, Li J, Yang X, Huang Y.
europepmc   +1 more source