Results 201 to 210 of about 506,209 (297)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Healthcare experiences and expectations of women survivors of domestic violence in Asia: a systemized review of the literature. [PDF]

Glob Health Action
Hossain MK, Brown J, Ansell H.
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Fear of cancer recurrence in thyroid cancer survivors and their spouses and its influencing factors

Huli yanjiu, 2022
YE Shoumei, CAO Zhiguo, YU Yousheng, PAN Yan, CHEN Benxin   +4 more
doaj  

"I Have Always Existed, but Never Been Noticed": A Hermeneutic Phenomenological Study of Social Frailty Among Prostate Cancer Survivors. [PDF]

J Multidiscip Healthc
Ye J, Zhuang S, Gu Y, Li N, Wan Y, Shen L, Xie C.   +6 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Research progress on continuous nursing for breast cancer survivors

Huli yanjiu, 2022
SHEN Tingting, LIN Huan, LIU Wenchong, GE Hongxia   +3 more
doaj  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Risk of subsequent primary melanoma in 68 002 five-year survivors of childhood and adolescent cancer in Europe: the PanCareSurFup cohort study. [PDF]

J Natl Cancer Inst
Shojaie B, Teepen JC, Winter DL, Gardner MP, Kaiser M, Grabow D, Ronckers CM, Byrne J, Skinner R, Alessi D, Baqaeen H, Allodji RS, Van Der Pal HJH, Jankovic M, Bagnasco F, Steliarova-Foucher E, Spycher BD, Sommer G, Bárdi E, Gudmundsdottir T, Maule MM, Michel G, Muraca M, Gunnes MW, Kenborg L, Hjalgrim H, Sacerdote C, Jakab Z, Haupt R, Wiebe T, Terenziani M, Zaletel LZ, Kremer LCM, Kuehni CE, Lähteenmäki PM, de Vathaire F, Hjorth L, Hawkins MM, Reulen RC.   +38 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source