Results 41 to 50 of about 60,248 (254)

Anthracycline-induced cardiomyopathy in childhood cancer survivors is associated with gene signatures of mitochondrial dysfunction—a COG ALTE03N1 report

Cardio-Oncology
Background Anthracycline-induced cardiomyopathy is a leading cause of morbidity and mortality in survivors of childhood cancer. The mitochondrion is a key mediator of the cytotoxic effects of anthracycline treatment and mitochondrial dysfunction is a ...
Patrick J. Trainor, Purnima Singh, Xuexia Wang, Noha Sharafeldin, Liting Zhou, Lindsey Hageman, Saro H. Armenian, Jill P. Ginsberg, Douglas S. Hawkins, Frank G. Keller, Melissa M. Hudson, Joseph P. Neglia, Wendy Landier, Smita Bhatia   +13 more
doaj   +1 more source

Benefit finding in adults living with somatic non-communicable chronic disease: a systematic review on the mean level and the prevalence

Frontiers in Psychiatry
IntroductionBenefit finding (BF) refers to the phenomenon of identifying positive changes from challenging circumstances. This review aimed to comprehensively assess the BF prevalence in persons with somatic non-communicable chronic diseases (pSNCDs ...
Zhunzhun Liu, Zhunzhun Liu, Xiang Hu, Volker Arndt, Melissa S. Y. Thong   +4 more
doaj   +1 more source

Prognostic Factors to Determine Survivorship of Meniscal Allograft Transplant: A Systematic Review

Orthopaedic Journal of Sports Medicine, 2021
Background: There is much room for improvement and optimization of meniscal allograft survivorship. Purpose: To understand prognostic factors for survivorship using evidence-based selection criteria in order to identify patients who would best benefit ...
Ding-yu Wang MD, Cassandra A. Lee MD, Yan-zhang Li MD, Bo Zhang MD, Nan Li PhD, Dong Jiang MD, Jia-kuo Yu MD, PhD   +6 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Alternative mRNA splicing in anthracycline-induced cardiomyopathy – a COG-ALTE03N1 report

Cardio-Oncology
Background Anthracycline-induced cardiomyopathy is a well-established adverse consequence in childhood cancer survivors. Altered mRNA expression in the peripheral blood has been found at the level of genes and pathways among anthracycline-exposed ...
Purnima Singh, David K. Crossman, Changde Cheng, Patrick J. Trainor, Noha Sharafeldin, Xuexia Wang, Liting Zhou, Lindsey Hageman, Saro H. Armenian, Frank M. Balis, Douglas S. Hawkins, Frank G. Keller, Melissa M. Hudson, Joseph P. Neglia, Jill P. Ginsberg, Wendy Landier, Smita Bhatia   +16 more
doaj   +1 more source

Cognitive and physical exercise to improve outcomes after surgery (COPE-iOS) study: protocol for a randomised, controlled trial in the USA examining the efficacy of a combined cognitive and physical exercise programme performed before and after major surgery in improving cognitive and functional outcomes for older adults

BMJ Open
Introduction Surgery and its resulting hospitalisation are associated with subsequent cognitive and functional decline. Interventions to reduce this decline have exhibited limited success.
Pratik P Pandharipande, Christopher G Hughes, Kimberly F Rengel, Kristin R Archer, Jim C Jackson, Rameela Raman, Onur M Orun, Terri Ellison, Susan W Vanston, Hope Ervin, Alana Lauck, Madison Provin   +11 more
doaj   +1 more source

Disease Course After Anti‐CD20 Discontinuation in Secondary Progressive Multiple Sclerosis—A Multicenter Long‐Term Longitudinal Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To describe long‐term outcomes after anti‐CD20 discontinuation in selected patients with secondary progressive multiple sclerosis (SPMS) who remained without subsequent disease‐modifying therapy (DMT). Methods We retrospectively analyzed data from four centers in Austria and Switzerland.
Ferdinand Otto, Dariia Kliushnikova, Richard Friedrich Radlberger, Sinan Yasaroglu, Tobias Moser, Andrea Harrer, Kitty Kratzer, Wolfgang Hitzl, Christiane Gradl, Martin Schmidauer, Patrick Roth, Harald Hegen, Peter Wipfler   +12 more
wiley   +1 more source

Marked Long‐Term Improvement in Lung Function in Melanoma Differentiation–Associated Protein 5 Antibody–Positive Dermatomyositis Patients: Experience of a Single‐Center Longitudinal Cohort in North America

Arthritis Care &Research, EarlyView.
Objective The objective of this study was to describe the longitudinal disease course and pulmonary outcomes of North American patients with melanoma differentiation–associated protein 5 (MDA5) antibody–associated dermatomyositis (DM). Methods Thirty patients with MDA5 antibody–associated DM were identified in a single‐center longitudinal cohort of 352
Jenice X. Cheah, Sangmee S. Bae, Tiffany De Leon, Yuna Lee, Rong Guo, David Elashoff, Jennifer Wang, Ani Shahbazian, Christina Charles‐Schoeman   +8 more
wiley   +1 more source

Metagenomic Association Uncovers Host Genotype‐Structured Rhizobacterial Networks and Novel Taxa That Enhance Soybean Salt Tolerance

Advanced Science, EarlyView.
An STI‐guided metagenomic association framework links soybean salt‐tolerance phenotypes with rhizosphere microbiome composition and network organization in natural saline soils. The approach identifies candidate beneficial taxa, including Thalassospira xiamenensis, and provides an efficient strategy for mining stress‐protective microbes from native ...
Yu Luo, Feng‐Li Kang, Qi‐Min Li, Wei‐Cai Yang   +3 more
wiley   +1 more source

Prevalence of lymphedema symptoms across cancer diagnoses and association with depression, pain interference and health-related quality of life

Acta Oncologica
Background and purpose: Lymphedema is a debilitating late effect of cancer treatments, yet its prevalence beyond breast cancer remains understudied. This study examined the prevalence of lymphedema symptoms across cancer diagnoses and their association ...
Gitte Sone Larsen, Christoffer Johansen, Annika von Heymann, Bolette Skjødt Rafn   +3 more
doaj   +1 more source