Results 51 to 60 of about 5,143,841 (243)

Characterisation of microbiota in saliva, bronchoalveolar lavage fluid, non-malignant, peritumoural and tumour tissue in non-small cell lung cancer patients: a cross-sectional clinical trial

Respiratory Research, 2020
Background While well-characterised on its molecular base, non-small cell lung cancer (NSCLC) and its interaction with local microbiota remains scarcely explored.
Rea Bingula, Edith Filaire, Ioana Molnar, Eve Delmas, Jean-Yves Berthon, Marie-Paule Vasson, Annick Bernalier-Donadille, Marc Filaire   +7 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Implementation strategies for hyperspectral unmixing using Bayesian source separation. [PDF]

, 2010
Positive Source Separation (BPSS) is a useful unsupervised approach for hyperspectral data unmixing, where numerical non-negativity of spectra and abundances has to be ensured, such in remote sensing. Moreover, it is sensible to impose a sum-to-one (full
Moussaoui, Saïd, Schmidt, Albrecht, Tréguier, Erwan, Maël Guiheneuf, Guiheneuf, Maël, Saïd Moussaoui, Erwan Treguier, Albrecht Schmidt, Nicolas Dobigeon, Dobigeon, Nicolas, Frédéric Schmidt, Schmidt, Frédéric   +11 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Spectro-temporal post-enhancement using MMSE estimation in NMF based single-channel source separation [PDF]

, 2013
We propose to use minimum mean squared error (MMSE) estimates to enhance the signals that are separated by nonnegative matrix factorization (NMF). In single channel source separation (SCSS), NMF is used to train a set of basis vectors for each source ...
Erdoğan, Hakan, Grais, Emad Mounir, Hakan Erdogan, Emad M. Grais   +3 more
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Blind source separation to enhance spectral and non-linear features of magnetoencephalogram recordings:Application to Alzheimer's disease [PDF]

, 2009
This work studied whether a blind source separation (BSS) and component selection procedure could increase the differences between Alzheimer's disease (AD) patients and control subjects' spectral and nonlinear features of magnetoencephalogram (MEG ...
Abasolo, Daniel, Hornero, Roberto, Escudero, Javier; id_orcid, Fernandez, Alberto, Hornero, R, Fernández, A, Escudero, J, Abásolo, D   +7 more
core   +1 more source

The 2010 signal separation evaluation campaign (SiSEC2010): Audio source separation

, 2022
S.114-122This paper introduces the audio part of the 2010 community-based Signal Separation Evaluation Campaign (SiSEC2010). Seven speech and music datasets were contributed, which include datasets recorded in noisy or dynamic environments, in addition ...
Ozerov, A., Gowreesunker, V., Nolte, G., Lutter, D., Araki, S., Sawada, H., Duong, N.Q.K., Theis, F.   +7 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Magnetic Susceptibility Separation in Brain [PDF]

, 2022
Quantitative susceptibility mapping (QSM) has become an area of intense interest in brain imaging due to its ability to quantify tissue magnetic susceptibility.
Hamidi Esfahani, Javad
core   +1 more source