Results 191 to 200 of about 302,377 (251)

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Integrated bite case management within a One Health framework for rabies elimination at the primary care level in Kerala, India: an implementation research protocol using a stepped-wedge cluster randomised design. [PDF]

BMJ Open
Nujum ZT, Luka MM, Raghunathan D, Beegum M, Sivanandan H, Bajaj P, Chandrashekar B, Pillai RK, Mathew T, Soman B, Asaria M, Karuppusami R, Gibson A, Sreenath MR, Jose A, John RR, Aparna S, Prathiush PR, Abraham SS, Narayanan SB, Chungath U, Indu PS, Ushakumari A, Sivaram R, Krishnapillai V, Aishwarya SS, Hampson K.   +26 more
europepmc   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Early post-marketing safety profile of resmetirom in FAERS: an exploratory assessment of statin co-reporting. [PDF]

Front Pharmacol
Liu Y, Chen J, Zhong H, Yu Y, Liu S, Yu Y.   +5 more
europepmc   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Machine Learning-Enhanced LC-HRMS Workflows for Suspect and Nontargeted Screening of Pesticide Residues in Fruits and Vegetables. [PDF]

Anal Chem
González S, Merino G, Guerrero Dallos JA.   +2 more
europepmc   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Prevalence and risk factors of keratoconus among school children in Oman: a population-based study. [PDF]

BMC Ophthalmol
Mohamed Z, Noushad B, Vankudre GS, Ayyappan J, Alkaabi A.   +4 more
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Endothelial and Vascular Toxicity Signals Associated With Doxorubicin: A Pharmacovigilance Analysis of the FDA Adverse Event Reporting System (FAERS) Database. [PDF]

Pharmacoepidemiol Drug Saf
Cerbito EF, Kattan L, Dhulkifle H, Korashy HM, Maayah ZH.   +4 more
europepmc   +1 more source