Results 71 to 80 of about 1,178,909 (237)

Colector multidireccional de partículas transportadas por el viento [PDF]

open access: yes, 2016
Número de publicación: ES2470090 A1 (20.06.2014) También publicado como: ES2470090 B1 (17.04.2015) Número de Solicitud: Consulta de Expedientes OEPM (C.E.O.) P201400329 (09.04.2014)Colector multidireccional del tipo de los utilizados para la recogida de
Asensio Grima, Carlos Manuel   +2 more
core  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

The direct rule in the Comparative Law: the suspension of Northern Ireland Assembly and the Catalonian Autonomy [PDF]

open access: yes, 2018
[EN] The direct rule is not only regulate in the Spanish legal order. Through this paper, firstly, we approach to the regulation of said figure in the d¡fferent legal systems of our surroundings and, secondly, get to know how the direct rule has been ...
Jardón Piérola, Leire
core  

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

open access: yesFEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li   +6 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

El escepticismo en el pensamiento político e histórico de David Hume [PDF]

open access: yes, 2018
This essay argues that Hume’s political and historical thought is well read as skeptical and skeptical in a way that roots it deeply in the Hellenistic traditions of both Pyrrhonian and Academical thought. It deploys skeptical instruments to undermine
Fosl, Peter S.
core  

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

open access: yesFEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

El rechazo y la interrupción del tratamiento de soporte vital en el derecho español [PDF]

open access: yes, 2009
A la luz de algunos supuestos de hecho acaecidos recientemente en nuestro derecho, el presente estudio examina la naturaleza constitucional y el vigente régimen jurídico de los supuestos de rechazo y solicitud de interrupción del tratamiento médico, con ...
Arruego Rodríguez, Gonzalo
core   +2 more sources

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

LOS EFECTOS DE LA SOLICITUD DE CONCILIACIÓN FRENTE A LA PRESCRIPCIÓN

open access: yesOpinión Jurídica, 2010
Este artículo propone un esquema de interpretación del artículo 21 de la ley 640 de 2001, que trata los efectos de la presentación de la solicitud de conciliación, frente al fenómeno de la prescripción y la caducidad de la eventual acción judicial que se
Alfonso Hernández Tous
doaj  

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