Results 111 to 120 of about 2,777,696 (401)
Drug Delivery, 2019 In our previous study, enrofloxacin-loaded docosanoic acid solid lipid nanoparticles (SLNs) could be effectively delivered to cells in vitro. In this study, its properties and exploitation as possible oral and intramuscular sustained release formulations
Yanfei Tao +10 more
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Driven to Failure: An Empirical Analysis of Driver’s License Suspension in North Carolina [PDF]
, 2020 A person’s interest in a driver’s license is “substantial,” and as the U.S. Supreme Court has observed, the suspension of a license by the state can result in “inconvenience and economic hardship suffered,” including because a license may be “essential ...
Crozier, William E., Garrett, Brandon L.
core +1 more source
Out-of-School Suspension and Expulsion
Pediatrics, 2013 The primary mission of any school system is to educate students. To achieve this goal, the school district must maintain a culture and environment where all students feel safe, nurtured, and valued and where order and civility are expected standards of ...
Jeffrey H. Lamont +10 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Suspension systems for ground testing large space structures [PDF]
A research program is documented for the development of improved suspension techniques for ground vibration testing of large, flexible space structures. The suspension system must support the weight of the structure and simultaneously allow simulation of
Friedman, Inger P. +3 more
core +1 more source
Magnetic suspension options for spacecraft inertia-wheel applications [PDF]
, 1984 Design criteria for spacecraft inertia-wheel suspensions are listed. The advantages of magnetic suspensions over other suspension types for spacecraft inertia-wheel applications are cited along with the functions performed by magnetic suspension.
Downer, J. R.
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Specifics of determining the forces are applied to the suspensions of conveyor with suspended belt and distributed drive, depending on their spatial configuration on the route [PDF]
Научно-технический вестник Брянского государственного университета, 2015 The basic version of the route, which includes the main areas of transportation of conveyor with suspended belt and distributed drive, was reviewed. Action of the suspension on respective areas, which occurs at moving of their, was ana-lyzed.
Tolkachev E.N.
doaj
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source