Results 51 to 60 of about 943,688 (258)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

[Review of] Sipho Sepamla. A Ride on the Whirlwind: A Novel of Soweto [PDF]

open access: yes, 1985
South African poet, playwright, and teacher Sipho Sepamla has in his second novel, produced a fictional but tensely revealing narrative of events surrounding the 1976 Soweto riots. Dedicated to the young heroes of the day, the novel chronicles daily life
Abbott, Linda M. C.
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Conspiracy Theories and Their Investigator(s) [PDF]

open access: yes, 2017
A reply to Patrick Stokes' 'Reluctance and Suspicion'—itself a reply to an early piece by myself replying to Stokes—in which I clarify what it is I intend when talking about how we should investigate conspiracy ...
Dentith Matthew, R. X.
core  

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Impact of COVID-19 on vaccination programs: adverse or positive?

open access: yesHuman Vaccines & Immunotherapeutics, 2020
The COVID-19 pandemic has posed multiple substantial challenges, affecting not only public health but also economic systems, socio-cultural patterns, and political institutions.
Inayat Ali
doaj   +1 more source

'Visibility brings with it responsibility': Using a pragmatic performance approach to explore a political philosophy of technology [PDF]

open access: yes, 2017
With the emergence, suspicion and social acceptance of ubiquitous communications technology thoroughly plumbed and the digital age already wondering what it is going to rename itself in light of ever more fluid and complex technologies, this paper asks ...
D'Arcy, Geraint
core   +4 more sources

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

open access: yesAging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef   +2 more
wiley   +1 more source

Suspicion of Motives Predicts Minorities' Responses to Positive Feedback in Interracial Interactions. [PDF]

open access: yes, 2016
Strong social and legal norms in the United States discourage the overt expression of bias against ethnic and racial minorities, increasing the attributional ambiguity of Whites' positive behavior to ethnic minorities. Minorities who suspect that Whites'
Kunstman, Jonathan W   +5 more
core  

Home - About - Disclaimer - Privacy