Results 81 to 90 of about 9,540,642 (235)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Pengungkapan Perubahan Iklim dalam Laporan Keberlanjutan PT Unilever Indonesia Tbk 2023

Jurnal Akutansi Manajemen Ekonomi Kewirausahaan
This article aims to analyze the application of the 2021 GRI Standards in uncovering issues related to climate change in the 2023 PT Unilever Indonesia Tbk poverty report through qualitative methods.
Shofiatus Sa'diyah
doaj   +1 more source

The Role of the Sharia Supervisory Board in Moderating the Relationship Between Sustainability Reports and Earnings Management in Islamic Banking [PDF]

International Journal of Management, Accounting and Economics
Earnings Management is manipulation to reported profit​ so that reported profit makes a loss No represent real economic condition of a company. This research aims to analyze certain variables for earnings management in Islamic banking.
Risma Laida, Lilik Handajani, Dwi Putra Sakti   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Overview Report - Think Tank 2: Sport Mega-Event Impacts, Leveraging, and Legacies

, 2011
On November 11-12, 2011 the UBC Centre for Sport and Sustainability held its second think tank on the topic of Sport Mega-Event Impacts, Leveraging, and Legacies.
Centre for Sport and Sustainability
core   +1 more source

Board characteristics and sustainability report quality: Profitability as a moderating variable

Journal of Accounting and Investment
Research aims: This research aims to determine the influence of board characteristics on the quality of sustainability reports and examine the role of profitability as a moderating variable in manufacturing companies in Indonesia.
Marfuah Marfuah, Erica Mariah Salma Hamsyah   +1 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Sustainability Report

, 2018
West-Life has worked with all stakeholders involved in the development, use and evaluation of services offered through the West-Life web-portal to identify and execute a sustainability solution for their future use. Information was gathered on the West-Life service provision, use by the structural biology community and the ability of ARIA (Instruct ...
openaire   +1 more source