Results 171 to 180 of about 292,782 (296)

Pursuing multifaceted-disciplinarity to enrich the future of justice in sustainability science. [PDF]

iScience
Sharma V, Roney SH, Olaomo O, Chapman O, Fernández CA, Chang M.   +5 more
europepmc   +1 more source

Data on the scope of the literature on participatory sustainability science 2000-2018: Bibliography and meta-analysis of selected studies. [PDF]

Data Brief, 2020
Musch AK, von Streit A.
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Simulating institutional heterogeneity in sustainability science. [PDF]

Proc Natl Acad Sci U S A
Davidson MR, Filatova T, Peng W, Verbeek L, Kucuksayacigil F.   +4 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Crossing the wicked frontier. Why sustainability science needs integrative research. [PDF]

R Soc Open Sci
Hewitt RJ.
europepmc   +1 more source

Assessment of sustainability science education criteria in online-learning through fuzzy-operational and multi-decision analysis and professional survey. [PDF]

Heliyon, 2020
Jeong JS, González-Gómez D.
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Equity and modeling in sustainability science: Examples and opportunities throughout the process. [PDF]

Proc Natl Acad Sci U S A
Giang A, Edwards MR, Fletcher SM, Gardner-Frolick R, Gryba R, Mathias JD, Venier-Cambron C, Anderies JM, Berglund E, Carley S, Erickson JS, Grubert E, Hadjimichael A, Hill J, Mayfield E, Nock D, Pikok KK, Saari RK, Samudio Lezcano M, Siddiqi A, Skerker JB, Tessum CW.   +21 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source