Results 71 to 80 of about 13,042 (302)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Personal norms of sustainability and their impact on management – The case of rangeland management in semi-arid regions [PDF]

We empirically study personal norms of sustainability, conceptualized according to the normactivation theory and operationalized under the notion of strong ecological-economic sustainability, for commercial cattle farmers in semi-arid rangelands of ...
Stefan Baumgaertner, Roland Olbrich, Martin F. Quaas   +2 more
core  

Understanding the Repurchase Intention of Premium Economy Passengers Using an Extended Theory of Planned Behavior

, 2019
This study investigates the repurchase intention of passengers who have experienced premium economy class. To achieve the research purpose, we examine the relationship among psychological factors, perceived price, perceived service quality, perceived ...
Jun Hwan Kim, Hyun Cheol Lee
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The role of environmental knowledge, subjective norms, perceived behavioral control, and institutional support in social media advocacy for geoscience-informed sustainability practices

Discover Sustainability
With the rise of the digital age, social media platforms have been utilized for a wide range of purposes; however, their potential for advancing geoscience-informed sustainability initiatives remains underexplored across many contexts.
Femi Emmanuel Ikuemonisan, Yusuf Olanrewaju Kayode, Oluwaseyi Omowunmi Popogbe, Oluyinka Victoria Ikuomenisan   +3 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Pro-environmental behavior and the theory of planned behavior: A state of the art science mapping [PDF]

Purpose: This science mapping analysis aims to discern current, emerging and future trends of pro-environmental behavior and the theory of planned behavior (TPB).
Mohd Hanafiah, Ahmad, Wider, Walton, Laili, Zulkepeli, Muhammad Ashraf, Fauzi, Syed Radzi, Rahamaddulla, Norazah, Mohd Suki   +5 more
core   +1 more source

Environmentally conscious consumption patterns in Hungarian households [PDF]

, 2011
This article provides a comprehensive review of the literature on the theoretical aspects of sustainable consumption. The conditions for consumers’ social responsibility and the formation of environmentally conscious behavior patterns will also be ...
Ágnes Hofmeister-Tóth, Marianna Piskóti, Hofmeister Tóth, Ágnes, Kata Kelemen, Kelemen, Kata, Piskóti, Marianna   +5 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source