Results 81 to 90 of about 76,851 (267)

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Urban green spaces as a climate adaptation strategy. Case study in Geneva, Switzerland

City and Environment Interactions
In a context marked by the urgency of climate change, dwindling resources, and environmental crisis, concrete action towards ecological transition and climate adaptation is a top priority for urban areas.
Sophie Lufkin, Emmanuel Rey
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Upcycling Prefabricated Building Materials to Develop Pavilions for Community Gardens in Huddersfield, UK

Proceedings
As average temperatures in the UK continue to rise, and the effects of climate change are felt across communities, the government has revised requirements for urban development pertaining to Biodiversity Net Gain and access to green spaces (under the ...
Yun Gao, Manas Murthy, Tamiris Capellaro Ferreira, Nwakaego Onyenokporo, Hemen Galal, Nic Clear   +5 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

A sustainable material for sustainable architecture: wood in parasite architecture

Congresso Internacional sobre Patologia e Reabilitação das Construções, 2021
Rinaldi S., Frunzio G., Guadagnuolo M., Di Gennaro L., Massaro L.   +4 more
openaire   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Assessment of Health-Oriented Layout and Perceived Density in High-Density Public Residential Areas: A Case Study of Shenzhen

Buildings
Rapid urbanization has intensified public housing development and building density, posing significant challenges to residents’ well-being and urban sustainability. With the population of the Greater Bay Area on the rise, enhancing the spatial quality of
Guangxun Cui, Menghan Wang, Yue Fan, Fei Xue, Huanhui Chen   +4 more
doaj   +1 more source

Towards the microbial home: An overview of developments in next-generation sustainable architecture. [PDF]

Microb Biotechnol, 2023
Armstrong R.
europepmc   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source