Results 71 to 80 of about 67,132 (267)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Editorial: New Horizons for Sustainable Architecture

Tema, 2021
Vincenzo Sapienza
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

A Study on the Effect of Dynamic Photovoltaic Shading Devices on Energy Consumption and Daylighting of an Office Building

Buildings
Photovoltaic shading devices (PVSDs) have the dual function of providing shade and generating electricity, which can reduce building energy consumption and improve indoor daylighting levels.
Yan Jiang, Zongxin Qi, Shenglin Ran, Qingsong Ma   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Effects of Dynamic Increases in Indoor CO₂ Concentration on Daytime Sleepiness: An EEG-Based Study

Buildings
Elevated indoor carbon dioxide (CO2) concentrations are increasingly recognized as a critical determinant of occupant health and cognitive performance; however, the neurophysiological mechanisms linking CO2 exposure to daytime sleepiness remain a subject
Baiyi Guo, Wenhao Wang, Baowen Yan, Hongbo Fan   +3 more
doaj   +1 more source

A Modular Timber Construction System for the Sustainable Vertical Extension of Office Buildings

Designs, 2018
Most European cities are facing urban densification issues. In this context, a solution to create usable spaces without additional pressure on land consists in the vertical extension of existing buildings.
Aleksis Dind, Sophie Lufkin, Emmanuel Rey   +2 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

A Systematic Review: Examining the Impacts of Artificial Intelligence

Journal of Artificial Intelligence in Architecture
Since its breakthrough in the mid-20th century, Artificial Intelligence (AI) has held great promises for improving the capacity of urban planning to address complex problems.
David Chow, Catharina Dwi Astuti Depari, Eva Gabriella   +2 more
doaj   +1 more source