Results 61 to 70 of about 4,297,113 (190)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
BuildingsPhotovoltaic shading devices (PVSDs) have the dual function of providing shade and generating electricity, which can reduce building energy consumption and improve indoor daylighting levels.
Yan Jiang +3 more
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Leading by example? : not exactly… : SDC commentary on the Sustainable Development in Government Report 2005 [PDF]
, 2012 Sustainable Development Commission commentary on the 'Sustainable Development in Government Report 2005'.Publisher ...
Sustainable Development Commission
core +2 more sources
Effects of Dynamic Increases in Indoor CO2 Concentration on Daytime Sleepiness: An EEG-Based Study
BuildingsElevated indoor carbon dioxide (CO2) concentrations are increasingly recognized as a critical determinant of occupant health and cognitive performance; however, the neurophysiological mechanisms linking CO2 exposure to daytime sleepiness remain a subject
Baiyi Guo +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Mainstreaming sustainable regeneration : a call to action [PDF]
, 2012 Contents: [Part 1]. Main publication – Part 2. Supporting documentsThis report is the culmination of 18 month’s investigation by the Sustainable Development Commission into how neighbourhood regeneration can be made more sustainable.Publisher ...
Sustainable Development Commission
core +2 more sources
A Systematic Review: Examining the Impacts of Artificial Intelligence
Journal of Artificial Intelligence in ArchitectureSince its breakthrough in the mid-20th century, Artificial Intelligence (AI) has held great promises for improving the capacity of urban planning to address complex problems.
David Chow +2 more
doaj +1 more source