Results 41 to 50 of about 4,297,113 (190)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
SUSTAINABLE ARCHITECTURE LEVELS
Journal of EngineeringSustainable architecture has became one of the most important architectural concepts on earth today because of the energy crises. Architecture is concerned as the largest energy consuming field ,so that one of the main goals of modern architecture is ...
عمار سالم
doaj +1 more source
Scientific Reports, 2021 Mycelium, as the root of fungi, is composed of filamentous strands of fine hyphae that bind discrete substrate particles into a block material. With advanced processing, dense mycelium-bound composites (DMCs) resembling commercial particleboards can be ...
Xin Ying Chan +4 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The effect of replacing aggregates with oyster shell powder on the performance of asphalt concrete
Materiales de ConstruccionIn response to the global trend towards achieving net zero emissions, various industries are actively promoting the circular economy. Central to this goal is the strategic utilization of alternative materials to replace virgin materials, thereby ...
J.R. Chang, Y.Y. Lo
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Complexity, 2021 Metropolitan areas are important for engaging in fierce global competition. Cities in metropolitan areas in China are generally characterized by a core-periphery structure. The Yangtze River Delta metropolitan area (YRD) is a national strategic region in
Jieying Yang +3 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
The impact of electric heating cape on local thermal sensation and thermal comfort of officers
Scientific ReportsThis study focuses on evaluating the thermoregulatory performance of a graphene-based electric heating cape and determining its optimal temperature for use in cool indoor environments during winter.
Yuxi Wang +4 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
BuildingsThermal comfort in public buildings is crucial for occupant well-being and energy efficiency. This study employs TRNSYS software to simulate the effects of thermal mass, window performance, and window–wall ratio (WWR) on summer thermal comfort.
Ran Cheng +5 more
doaj +1 more source