Results 71 to 80 of about 76,851 (267)
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Editorial: New Horizons for Sustainable Architecture
Tema, 2021 Vincenzo Sapienza
doaj +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
BuildingsPhotovoltaic shading devices (PVSDs) have the dual function of providing shade and generating electricity, which can reduce building energy consumption and improve indoor daylighting levels.
Yan Jiang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Effects of Dynamic Increases in Indoor CO2 Concentration on Daytime Sleepiness: An EEG-Based Study
BuildingsElevated indoor carbon dioxide (CO2) concentrations are increasingly recognized as a critical determinant of occupant health and cognitive performance; however, the neurophysiological mechanisms linking CO2 exposure to daytime sleepiness remain a subject
Baiyi Guo +3 more
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
A Systematic Review: Examining the Impacts of Artificial Intelligence
Journal of Artificial Intelligence in ArchitectureSince its breakthrough in the mid-20th century, Artificial Intelligence (AI) has held great promises for improving the capacity of urban planning to address complex problems.
David Chow +2 more
doaj +1 more source
A Modular Timber Construction System for the Sustainable Vertical Extension of Office Buildings
Designs, 2018 Most European cities are facing urban densification issues. In this context, a solution to create usable spaces without additional pressure on land consists in the vertical extension of existing buildings.
Aleksis Dind +2 more
doaj +1 more source