Results 81 to 90 of about 68,953 (307)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Spatial (in)justice shaping the home as a space of work
Buildings & CitiesDrawing on an extensive literature review, this study examines how injustices manifest in space and the role of space in engendering injustices when associated with working at home.
Dalia Milián Bernal +5 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Architectural sustainability: A new inspiration [PDF]
SAJ - Serbian Architectural Journal, 2016 Sustainable building, use of local materials, responsible use of soils, re-use, adaptability to climate, are all concepts that became worldwide part of the vocabulary of contemporary architectural design since the energy expenditure in the construction sector has proved to be of such magnitude to be unsustainable in the medium and long term.
openaire +3 more sources
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
The Bio-adaptive algae contribution for sustainable architecture
IOP Conference Series: Earth and Environment, 2019 By studying nature, engineers, architects & designers can gain inspiration for designs that have never existed before; therefore applying bio mimicry can affect our buildings.
D. Elmeligy, Z. Elhassan
semanticscholar +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Natural materials in sustainable architecture building system
IOP Conference Series: Materials Science and Engineering, 2019 Modern architecture is increasingly in need of solutions that form a sustainable environment. One of the important techniques is the use of natural materials.
S. Ilvitskaya, V. Lobkov, T. Lobkova
semanticscholar +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Editorial: New Horizons for Sustainable Architecture
Tema, 2021 Vincenzo Sapienza
doaj +1 more source