Results 141 to 150 of about 9,662,874 (348)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Understanding the Connections Between Consumer Motivations and Buying Behavior: The Case of the Local Food System Movement [PDF]

open access: yes
Local and organic food systems represent some of the many food sector innovations of the past decade that signal that consumers are increasingly diverse and have heterogeneous preferences that reflect their unique values and preferences (Thilmany, Bond ...
Nurse, Gretchen   +2 more
core   +1 more source

Green revolution 2.0: a sustainable energy path [PDF]

open access: yes, 2010
This repository item contains a single issue of Sustainable Development Insights, a series of short policy essays that began publishing in 2008 by the Boston University Frederick S. Pardee Center for the Study of the Longer-Range Future. The series seeks
Kulatilaka, Nalin
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Critical Portrait of Vocational High School Accounting Teachers Sustainable Awareness in Indonesia

open access: yesJurnal Teknologi Pendidikan
about their actions’ environmental and social impact, Education teaches students to think critically and responsibly towards the surrounding environment.
Sri Sumaryati   +3 more
doaj   +1 more source

Avoiding Chaos in Wonderland

open access: yes, 2006
Wonderland, a compact, integrated economic, demographic and environmental model is investigated using methods developed for studying critical phenomena.
Bankes   +18 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

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