Results 81 to 90 of about 159,665 (238)

TMC4 localizes to multiple taste cell types in the mouse taste papillae

open access: yesFEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata   +6 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

Recent Progress in Experimental Techniques for Thin Liquid Film Evaporation

open access: yesEnergies
Thin liquid film evaporation leverages latent heat and low thermal resistance to achieve superior heat transfer capabilities, making it pivotal for next-generation high-heat-flux thermal management systems.
Yu Zhang   +4 more
doaj   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

open access: yesFEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen   +6 more
wiley   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

open access: yesFEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Prospective dynamic average and marginal electricity emission factors for Germany until 2070: a methodological extension incorporating energy storage

open access: yesEnergy, Sustainability and Society
Background Life Cycle Assessment (LCA) of electricity consumption requires temporally resolved emission factors. Two established metrics are the Average Emission Factor (AEF), allocating total system impacts to consumed electricity, and the Marginal ...
Tobias Blanke   +4 more
doaj   +1 more source

Local area energy mapping approach for high-density heat pump deployment

open access: yesBuildings & Cities
A localised, data-driven approach is presented for the rapid and scalable deployment of heat pumps in high-density areas. This novel hyper-local methodology evaluates the technical feasibility and readiness of dwellings for heat pump deployment.
Rajat Gupta, Matt Gregg, Chenfei Liu
doaj   +1 more source

Wood-Veneer-Reinforced Mycelium Composites for Sustainable Building Components. [PDF]

open access: yesBiomimetics (Basel), 2022
Özdemir E   +10 more
europepmc   +1 more source

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